catalog number :
MBS532353
products full name :
Ricin antibody
products short name :
[Ricin]
products name syn :
[Monoclonal Ricin; Anti-Ricin; RCA60; Ricinus Communis]
other names :
[Ricin; Ricin; Ricin precursor; Ricin A chain (EC:3.2.2.22)Alternative name(s):rRNA N-glycosidase]
other gene names :
[RCOM_2159910]
uniprot entry name :
RICI_RICCO
reactivity :
This anitbody recognizes the A-chain of RCA60
purity :
Ricin antibody was purified by chromatography on protein G Sepharose.
form :
Liquid in PBS (pH7.4) with 0.09% Sodium Azide as presevative.
storage stability :
Store at 4°C. Do Not Freeze!
tested application :
ELISA (EIA), Western Blot (WB)
other info1 :
Biological Significance: Ricin is a toxalbumin which may be extracted from the castor bean. Ricin is poisonous if inhaled, injected, or ingested, acting as a toxin by the inhibition of protein synthesis. It is resistant, but not impervious, to digestion by peptidases.
other info2 :
Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
products categories :
Drugs & Toxicology
products description :
Mouse monoclonal Ricin antibody
uniprot summary :
Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity).