IL2Ra antibody | MyBioSource MBS532180 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

IL2Ra antibody

catalog :

MBS532180

quantity :

0.5 mg

price :

310 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

M912289

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS532180

products type :

Antibody

products full name :

IL2Ra antibody

products short name :

IL2Ra

products name syn :

Monoclonal IL2Ra; Anti-IL2Ra; MCGF; IL 2Ra; IL2Ra; P-cell stimulation factor; IL-2Ra; Multi-CSF; HCGF; Mast cell growth factor; Interleukin 3; IL-3

other names :

interleukin-2 receptor subunit alpha isoform 1; Interleukin-2 receptor subunit alpha; interleukin-2 receptor subunit alpha; interleukin 2 receptor, alpha; TAC antigen; p55; CD_antigen: CD25

products gene name :

IL2Ra

other gene names :

IL2RA; IL2RA; p55; CD25; IL2R; TCGFR; IDDM10; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA

uniprot entry name :

IL2RA_HUMAN

clonality :

Monoclonal

isotype :

IgG2a kappa

clone :

M912289

host :

Mouse

reactivity :

Human IL-2 receptor

sequence length :

272

form :

Sterile filtered lyophilized powder from PBS. Centrifuge the vial prior to opening. Reconstitute in sterile water for a final concentration of 1.0mg/ml

concentration :

500ug, lyophilized

storage stability :

Ships ambient or refrigerated. Upon receipt store at 4 degree C short term: -20 degree C long term. Avoid repeated freeze-thaw cycles.

tested application :

ELISA (EIA), Inhibition, Western Blot (WB)

app notes :

ELISA: 4-8 ug/ml. Inhibition: 1-1.5 ug/ml

other info1 :

Biological Significance: IL3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL3 enhances thrombopoieses, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL3 may have additional immunoregulatory roles. Many of the IL3 activities depend upon co-stimulation with other cytokines. IL3 is species-specific, variably glycosylated cytokine.

other info2 :

Immunogen: Hi-5 Insect cells

products categories :

Cytokines & Growth Factors

products description :

Mouse monoclonal IL2Ra antibody

ncbi gi num :

4557667

ncbi acc num :

NP_000408.1

ncbi gb acc num :

NM_000417.2

uniprot acc num :

P01589

ncbi pathways :

Arf6 Trafficking Events Pathway (137954); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Calcium Signaling In The CD4+ TCR Pathway (137941); Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Downstream Signaling In Naive CD8+ T Cells Pathway (138018); Endocytosis Pathway (102279); Endocytosis Pathway (102181); G Beta:gamma Signalling Through PI3Kgamma Pathway (119540)

ncbi summary :

The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]

uniprot summary :

IL2RA: Receptor for interleukin-2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 10p15-p14. Cellular Component: plasma membrane; integral to membrane; external side of plasma membrane. Molecular Function: interleukin-2 receptor activity; drug binding; interleukin-2 binding. Biological Process: Notch signaling pathway; regulation of T cell homeostatic proliferation; apoptosis; negative regulation of immune response; negative regulation of defense response to virus; positive regulation of activated T cell proliferation; cell proliferation; negative regulation of T cell proliferation; cell surface receptor linked signal transduction; inflammatory response to antigenic stimulus; positive regulation of T cell differentiation; negative regulation of inflammatory response; immune response; inflammatory response; activated T cell apoptosis. Disease: Interleukin 2 Receptor, Alpha, Deficiency Of; Diabetes Mellitus, Insulin-dependent, 10

size1 :

0.5 mg

price1 :

310 USD

more info or order :

MyBioSource product webpage