BMP7 antibody | MyBioSource MBS532118 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

BMP7 antibody

catalog :

MBS532118

quantity :

0.5 mg

price :

310 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

M912263

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS532118

products type :

Antibody

products full name :

BMP7 antibody

products short name :

BMP7

products name syn :

Monoclonal BMP7; Anti-BMP7; BMP 7; BMP-7; BMP7; 7; Bone Morphogenetic; OP-1

other names :

bone morphogenetic protein 7, partial; Bone morphogenetic protein 7; bone morphogenetic protein 7; bone morphogenetic protein 7; Bone morphogenetic protein 7

products gene name :

BMP7

other gene names :

BMP7; BMP7; OP-1

uniprot entry name :

Q9H2W7_HUMAN

clonality :

Monoclonal

isotype :

IgG1 kappa

clone :

M912263

host :

Mouse

reactivity :

Human BMP7

sequence length :

139

form :

Lyophilized from PBS.

concentration :

500ug, lyophilized

storage stability :

Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.

tested application :

ELISA (EIA), Inhibition, Western Blot (WB)

app notes :

ELISA: 2-4 ug/ml

other info1 :

Biological Significance: TGF beta family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. BMP-7, also known as osteogenic protein-1 or OP-1, is a potent bone inducing agent, which in the presence of appropriate osteoconductive carrier (e.g. collagen sponge or synthetic hydroxyapatite) can be used in the treatment of bone defects. A bone-graft substitute, called OP-1TM implant, made of recombinant human BMP-7 associated with bovine bone-derived collagen, has recently been approved by the FDA as a device for treating critical-size bone fractures.

other info2 :

Immunogen: BMP7 antibody was raised in mouse using recombinant human BMP-7/OP-1 as the immunogen.

products categories :

Differentiation & Development

products description :

Mouse monoclonal BMP7 antibody

ncbi gi num :

12003264

ncbi acc num :

AAG43508.1

uniprot acc num :

Q9H2W7

ncbi mol weight :

28.8 kDa (predicted detection band MW)

ncbi pathways :

ALK2 Signaling Events Pathway (137983); BMP Receptor Signaling Pathway (137948); BMP Signaling Pathway (1084755); BMP Signaling Pathway (1108218); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Elastic Fibre Formation Pathway (730310); Endochondral Ossification Pathway (198812); Extracellular Matrix Organization Pathway (576262); Hippo Signaling Pathway (749777)

ncbi summary :

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. [provided by RefSeq, Jul 2008]

uniprot summary :

BMP7: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1. Expressed in the kidney and bladder. Lower levels seen in the brain. Belongs to the TGF-beta family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 20q13. Cellular Component: extracellular matrix; extracellular space; extracellular region. Molecular Function: heparin binding; protein binding; growth factor activity; cytokine activity; transforming growth factor beta receptor binding. Biological Process: negative regulation of MAP kinase activity; response to peptide hormone stimulus; axon guidance; extracellular matrix organization and biogenesis; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; negative regulation of NF-kappaB import into nucleus; embryonic pattern specification; response to estradiol stimulus; negative regulation of cell cycle; BMP signaling pathway; regulation of apoptosis; response to vitamin D; epithelial cell differentiation; ureteric bud development; dendrite development; mesonephros development; skeletal development; embryonic limb morphogenesis; ossification; positive regulation of heterotypic cell-cell adhesion; positive regulation of bone mineralization; odontogenesis of dentine-containing teeth; positive regulation of osteoblast differentiation; negative regulation of neuron differentiation; mesenchymal cell differentiation; mesoderm formation; branching morphogenesis of a tube; inhibition of NF-kappaB transcription factor; cartilage development; negative regulation of mitosis; epithelial to mesenchymal transition; negative regulation of Notch signaling pathway; negative regulation of phosphorylation; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; embryonic camera-type eye morphogenesis; negative regulation of transcription, DNA-dependent; metanephros development; neurite morphogenesis; growth

size1 :

0.5 mg

price1 :

310 USD

more info or order :

MyBioSource product webpage