catalog number :
MBS532110
products full name :
CD38 antibody (Azide Free)
products short name :
CD38
products name syn :
Monoclonal CD38; Anti-CD38; CD-38; CD 38; CD38
other names :
CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; CD38 molecule; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20); 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD_antigen: CD38
products gene name :
CD38
other gene names :
CD38; CD38; T10; ADPRC 1; ADPRC 1; cADPr hydrolase 1
uniprot entry name :
CD38_HUMAN
form :
Supplied as a liquid in PBS
concentration :
0.5 mg/ml
storage stability :
Aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles
tested application :
Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP)
other info1 :
Biological Significance: CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling.
other info2 :
Immunogen: CD38 antibody (Azide free) was raised in rat using CD38 as the immunogen.
products categories :
Immunology
products description :
Rat monoclonal CD38 antibody (Azide Free)
ncbi acc num :
BAA18966.1
ncbi mol weight :
13,788 Da
ncbi pathways :
Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Epstein-Barr Virus Infection Pathway (585562); Epstein-Barr Virus Infection Pathway (587115); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Metabolic Pathways (132956); Nicotinate And Nicotinamide Metabolism Pathway (83014); Nicotinate And Nicotinamide Metabolism Pathway (400); Oxytocin Signaling Pathway (952859)
ncbi summary :
CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling. [provided by RefSeq, Jul 2008]
uniprot summary :
CD38: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. Belongs to the ADP-ribosyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Hydrolase; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Apoptosis; Lyase; EC 3.2.2.6; EC 2.4.99.20; Cell surface; Cell cycle regulation. Chromosomal Location of Human Ortholog: 4p15. Cellular Component: cell surface; membrane; plasma membrane; integral to membrane; nucleus. Molecular Function: transferase activity; phosphorus-oxygen lyase activity; NAD+ nucleosidase activity; NAD(P)+ nucleosidase activity. Biological Process: response to drug; response to retinoic acid; metabolic process; positive regulation of transcription, DNA-dependent; positive regulation of insulin secretion; female pregnancy; signal transduction; positive regulation of cell growth; response to estradiol stimulus; B cell receptor signaling pathway; elevation of cytosolic calcium ion concentration; response to hydroperoxide; positive regulation of vasoconstriction; response to hypoxia; positive regulation of B cell proliferation; response to progesterone stimulus; negative regulation of bone resorption; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis