catalog number :
MBS532093
products full name :
Cytokeratin 19 antibody
products short name :
Cytokeratin 19
products name syn :
Monoclonal Cytokeratin 19; Anti-Cytokeratin 19; Cytokeratin 19; Cytokeratin -19; Keratin K19
other names :
cytokeratin 19, partial; Keratin, type I cytoskeletal 19; Cytokeratin-19; CK-19; Keratin-19; K19
other gene names :
KRT19; CK-19; K19
uniprot entry name :
K1C19_HUMAN
reactivity :
Bovine, Fish, Human, Rabbit, Rat
specificity :
Human keratin K19
purity :
Protein A affinity chromatography
form :
Supplied as a lyophilized powder. Reconstitute in 1 ml dist. water (final solution contains 0.09 % NaN3, 0.5% BSA in PBS buffer, pH 7.4)
storage stability :
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze-thaw cycles.
tested application :
ELISA (EIA), Immunohistochemistry (IHC) Formalin, Western Blot (WB)
app notes :
IHC-F: 1:10. This antibody can be used as the detection antibody in combination with MBS831144 as the capture antibody in sandwich ELISA.
other info1 :
Biological Significance: Cytokeratins are proteins of keratin-containing intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue. Cytokeratin represents an excellent marker for the discrimination of specific subtypes of adenocarcinoma. Keratin, type I cytoskeletal 19 also known as cytokeratin-19 (CK-19) or keratin-19 (K19) is a protein that in humans is encoded by the KRT19 gene. Keratin 19 is a type I keratin.
other info2 :
Immunogen: Cytokeratin 19 antibody was raised in mouse using Keratin K19 from cultured human MCF-7 cells as the immunogen.
products categories :
Cancer
products description :
Mouse monoclonal Cytokeratin 19 antibody
ncbi acc num :
BAB40770.1
ncbi mol weight :
44,106 Da
uniprot summary :
K19: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 19 differs from all other IF proteins in lacking the C-terminal tail domain. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 17q21.2. Cellular Component: dystrophin-associated glycoprotein complex; costamere; intermediate filament; Z disc; sarcolemma. Molecular Function: protein binding; structural constituent of cytoskeleton; structural constituent of muscle; protein complex binding. Biological Process: viral reproduction; response to estrogen stimulus; sarcomere organization