antibody

CD22 antibody (PE)

MBS532086

0.1 mg

335 USD

monoclonal

rat

PE

2D6

human, mouse

flow cytometry, FACS

Antibody

CD22 antibody (PE)

CD22

Monoclonal CD22; Anti-CD22; CD-22; CD22; FceRII; CD 22

CD22, partial; CD22 protein; B-cell receptor CD22; CD22 molecule; CD22 protein

CD22

CD22; CD22; SIGLEC2; SIGLEC-2

Q9UQB2_HUMAN

Monoclonal

IgG1

2D6

Rat

Murine

40

Supplied as a liquid in PBS, with NaN3 added as preservative.

0.1 mg/ml

Store at 4 degree C.

Flow Cytometry (FC/FACS)

Biological Significance: CD22 or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases. CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signalling.

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Tag/Conjugate: PE. Immunogen: CD22 antibody (PE) was raised in rat using CD22 as the immunogen.

Immunology; Conjugated Monoclonal Antibodies

Rat monoclonal CD22 antibody (PE)

4126455

BAA36576.1

Q9UQB2

4,495 Da

B Cell Receptor Signaling Pathway (198909); B Cell Receptor Signaling Pathway (83081); B Cell Receptor Signaling Pathway (492); BCR Signaling Pathway (138058); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489)

CD22: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Cell surface. Chromosomal Location of Human Ortholog: 19q13.1. Cellular Component: integral to plasma membrane; external side of plasma membrane. Molecular Function: protein binding; carbohydrate binding. Biological Process: cell adhesion

0.1 mg

335 USD