catalog number :
MBS531999
products full name :
BMP4 antibody
products short name :
BMP4
products name syn :
Monoclonal BMP4; Anti-BMP4; BMP-4; BMP 4; BMP-2B; BMP4; DVR4; Bone Morphogenetic; 4
other names :
bone morphogenetic protein-4; Bone morphogenetic protein 4; bone morphogenetic protein 4; bone morphogenetic protein 4; Bone morphogenetic protein 2B; BMP-2B
products gene name :
BMP4
other gene names :
BMP4; BMP4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6; BMP2B; DVR4; BMP-4; BMP-2B
uniprot entry name :
BMP4_HUMAN
reactivity :
To be determined by end-user
form :
Lyophilized from PBS.
storage stability :
Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.
tested application :
ELISA (EIA), Inhibition, Western Blot (WB)
app notes :
ELISA: 4-8 ug/ml. Inhibition: 0.4-0.6 ug/ml. WB: 0.25-0.5 ug/ml
other info1 :
Biological Significance: Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF beta superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva.
other info2 :
Immunogen: BMP4 antibody was raised in mouse using highly pure recombinant human BMP-4 as the immunogen.
products categories :
Differentiation & Development
products description :
Mouse monoclonal BMP4 antibody
ncbi acc num :
AAC72278.1
ncbi mol weight :
31-36 kDa (predicted detection band MW)
ncbi pathways :
Adipogenesis Pathway 198832!!BMP Signaling Pathway 1084755!!BMP Signaling Pathway 1108218!!Basal Cell Carcinoma Pathway 83113!!Basal Cell Carcinoma Pathway 525!!Cardiac Progenitor Differentiation Pathway 712094!!Elastic Fibre Formation Pathway 730310!!Extracellular Matrix Organization Pathway 576262!!Glypican 3 Network Pathway 138084!!Heart Development Pathway 198802
ncbi summary :
The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. [provided by RefSeq, Jul 2008]