CD16 antibody | MyBioSource MBS531983 product information

product summary

request information :

company name :

MyBioSource

product type :

antibody

product name :

CD16 antibody

catalog :

MBS531983

quantity :

0.1 mg

price :

1345 USD

clonality :

monoclonal

host :

mouse

reactivity :

human

application :

flow cytometry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS531983

products type :

Antibody

products full name :

CD16 antibody

products short name :

CD16

products name syn :

Monoclonal CD16; Anti-CD16; FcgRIII; CD-16; CD-16; CD 16; CD16 FcgRIII; CD16; CD 16

other names :

CD16; Low affinity immunoglobulin gamma Fc region receptor III-A; low affinity immunoglobulin gamma Fc region receptor III-A; FcgammaRIIIA; CD16a antigen; fc-gamma RIII; Fc-gamma RIIIa; Fc-gamma RIII-alpha; igG Fc receptor III-2; Fc gamma receptor III-A; Fc-gamma receptor IIIb (CD16); neutrophil-specific antigen NA; Fc-gamma receptor III-2 (CD 16); immunoglobulin G Fc receptor III; Fc fragment of IgG, low affinity III, receptor for (CD16); Fc fragment of IgG, low affinity IIIa, receptor (CD16a); CD16a antigen; Fc-gamma RIII-alpha; Fc-gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcR-10; IgG Fc receptor III-2

products gene name :

CD16

other gene names :

FCGR3A; FCGR3A; CD16; FCG3; CD16A; FCGR3; IGFR3; FCR-10; FCRIII; FCGRIII; FCRIIIA; CD16A; FCG3; FCGR3; IGFR3; Fc-gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa

uniprot entry name :

FCG3A_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

3G8

host :

Mouse

specificity :

Human

purity :

CD16 antibody was purified by Protein A chromatography.

form :

50mM Na3PO4, pH 7.5, with 100mM KCL, and 150mM NaCl. No preservatives added.

concentration :

1.0 mg/ml

storage stability :

Store at 4 deg C. OPEN UNDER ASEPTIC CONDITIONS. Avoid repeated freeze/thaw cycles.

tested application :

Flow Cytometry (FC)

app notes :

FC: 10 ug/ml

other info1 :

Immunogen: CD16 antibody was raised in mouse using human polymorphonuclear leukocytes as the immunogen.

products categories :

Immunology; Monoclonal Antibodies

products description :

Mouse monoclonal CD16 antibody. Human CD16 is a low affinity receptor for complexed IgG and occurs in two distinct forms, as a glycosyl phosphtidyl inositol (GPI) anchored protein in granulocytes, and as an integral membrane protein on NK cells and macrophages.

ncbi gi num :

8176551

ncbi acc num :

AAB33925.2

uniprot acc num :

P08637

ncbi mol weight :

29,089 Da

ncbi pathways :

Adaptive Immune System Pathway 366160!!FCGR Activation Pathway 771578!!Fc Gamma R-mediated Phagocytosis Pathway 114228!!Fc Gamma R-mediated Phagocytosis Pathway 106590!!Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway 771577!!Immune System Pathway 106386!!Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway 106413!!Innate Immune System Pathway 106387!!Leishmaniasis Pathway 144181!!Leishmaniasis Pathway 144028

ncbi summary :

This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

Function: Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. Subunit structure: Exists as a heterooligomeric receptor complex with Fc epsilon receptor I gamma subunit and / or the CD3 zeta subunit. Interacts with INPP5D/SHIP1 . By similarity. Subcellular location: Cell membrane; Single-pass type I membrane protein . Potential. Secreted. Note: Exists also as a soluble receptor. Tissue specificity: Expressed on natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts. Post-translational modification: Glycosylated. Contains high mannose- and complex-type oligosaccharides.The soluble form is produced by a proteolytic cleavage. Miscellaneous: Encoded by one of two nearly indentical genes: FCGR3A (Shown here) and FCGR3B which are expressed in a tissue-specific manner. The Phe-203 in III-A determines the transmembrane domains whereas the 'Ser-203' in III-B determines the GPI-anchoring. Sequence similarities: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Sequence caution: The sequence BAD96988.1 differs from that shown. Reason: Erroneous initiation. The sequence BAD97015.1 differs from that shown. Reason: Erroneous initiation.

size :

0.1 mg

price :

1345 USD

more info or order :

MyBioSource product webpage