antibody

CD44 antibody

MBS531925

2 ml

605 USD

monoclonal

rat

nonconjugated

MAC329

human, dog, cow

immunohistochemistry, immunoprecipitation, flow cytometry, FACS, immunohistochemistry - paraffin section

Antibody

CD44 antibody

CD44

Monoclonal CD44; Anti-CD44; CD 44; Pgp1; HCAM; CD44; H-CAM; CD-44; chondroitin sulfate proteoglycan 8; MDU2; CSPG8; IN; CD44R; MDU3; hematopoietic cell E- and L-selectin ligand

CD44, partial; CD44 antigen; CD44 antigen; CD44 molecule (Indian blood group); CDw44; Epican; Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Heparan sulfate proteoglycan; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I; PGP-I; CD_antigen: CD44

CD44

CD44; CD44; IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III; LHR; MDU2; MDU3; MIC4; ECMR-III; PGP-1; PGP-I

CD44_HUMAN

Monoclonal

IgG1

MAC329

Rat

Bovine, Dog, Horse, Goat, Sheep

43

Pig

Concentrated tissue culture supernatant supplied in 0.2M tris-HCl pH7.4,5-10% FCS, and 0.09% NaN3.

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Flow Cytometry (FC/FACS), Immunohistochemistry (IHC) Formalin/Paraffin, Immunoprecipitation (IP)

Biological Significance: CD44 is a receptor for hyaluronic acid and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). CD44 function is controlled by its posttranslational modifications. One critical modification involves discrete sialofucosylations rendering the selectin-binding glycoform of CD44 called HCELL (for Hematopoietic Cell E-selectin/L-selectin Ligand). The HCELL glycoform was originally discovered on human hematopoietic stem cells and leukemic blasts, and was subsequently identified on cancer cells.

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling. Immunogen: CD44 antibody was raised in rat using purified porcine wCD44 as the immunogen.

Cancer

Rat monoclonal CD44 antibody

685122

AAB30429.1

P16070

15,635 Da

Cell Surface Interactions At The Vascular Wall Pathway 106062!!Cytokine Signaling In Immune System Pathway 366171!!Degradation Of The Extracellular Matrix Pathway 576263!!ECM-receptor Interaction Pathway 83068!!ECM-receptor Interaction Pathway 479!!Epstein-Barr Virus Infection Pathway 585562!!Epstein-Barr Virus Infection Pathway 587115!!Extracellular Matrix Organization Pathway 576262!!Glycosaminoglycan Metabolism Pathway 645297!!Hematopoietic Cell Lineage Pathway 83078

The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]

2 ml

605 USD