antibody

MUC1 Glycoprotein antibody

MBS531916

1 mg

565 USD

monoclonal

mouse

nonconjugated

M4H2

ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay, immunohistochemistry - paraffin section

Antibody

MUC1 Glycoprotein antibody

MUC1 Glycoprotein

Monoclonal MUC1 Glycoprotein; Anti-MUC1 Glycoprotein; Mucin-1; MU-1c; MU 1c; MUC1

mucin glycoprotein, partial; Mucin-1; mucin-1; mucin 1, cell surface associated; Breast carcinoma-associated antigen DF3; Cancer antigen 15-3; CA 15-3

MUC1

MUC1; MUC1; EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC; PUM; MUC-1; CA 15-3; KL-6; PUM; PEM; EMA; MUC1-NT; MUC1-alpha; MUC1-beta

MUC1_HUMAN

Monoclonal

IgG

M4H2

Mouse

Human

97

MUC1 Glycoprotein antibody was purified by chromatography on protein A Sepharose.

Protein A purified and supplied in PBS, pH 7.4, 0.1 % NaN3.

Store at 4 degree C.

ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin/Paraffin

Biological Significance: Cell surfaces associated mucin (MUC1) is a mucin, the protein part of which is encoded by the MUC1 gene in humans. Mucin proteins penetrate the membranes of epithelial cells, on the inner surface of the intestine and other organs. Mucin protects the body from infection by binding to pathogens. Overexpression of the mucin protein is often associated with colon and many other cancers.

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: MUC1 glycoprotein antibody was raised in mouse using high molecular weight (>300 kDa) glycoprotein from human milk-fat globule molecule as the immunogen.

Immunology

Mouse monoclonal MUC1 Glycoprotein antibody

4262069

AAD14369.1

P15941

28,297 Da

IL-7 Signaling Pathway (198857); Metabolism Of Proteins Pathway (106230); O-linked Glycosylation Pathway (1127679); O-linked Glycosylation Of Mucins Pathway (530747); Post-translational Protein Modification Pathway (161012); Termination Of O-glycan Biosynthesis Pathway (530748)

This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

MUC1: a large cell surface glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. Plays a role in adhesion and cell-cell interactions, metastasis and signaling. May provide a protective layer on epithelial surfaces. Direct or indirect interaction with actin cytoskeleton. Its cytoplasmic tail (MUC1CT) is involved in several signaling pathways, including those involving Ras, beta-catenin, p120 catenin, p53 and estrogen receptor alpha. MUC1CT also forms complexes with transcription factors, and then translocates to the nucleus by an unknown mechanism, where it is believed to influence the transcription of their target genes. MUC1CT has also been proposed to localize to mitochondrial membranes under conditions of genotoxic stress, where it attenuates the apoptotic pathway in response and confers resistance to apoptosis-inducing drugs. Aberrantly glycosylated forms expressed in human epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Nine alternatively spliced isoforms have been described. Isoforms 5 and 9 are secreted. Isoform 7, expressed only in tumor cells, is a receptor and binds the secreted isoform 5. The binding induces the phosphorylation of the isoform 7, alters cellular morphology and initiates cell signaling. Can bind to GRB2 adapter protein. Protein type: Motility/polarity/chemotaxis; Cell adhesion; Tumor suppressor; Actin-binding; Nuclear receptor co-regulator; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1q21. Cellular Component: extracellular space; cell surface; Golgi lumen; integral to plasma membrane; apical plasma membrane; nuclear chromatin; cytoplasm; vesicle. Molecular Function: protein binding; p53 binding; transcription cofactor activity. Biological Process: protein amino acid O-linked glycosylation; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; cellular protein metabolic process; regulation of transcription from RNA polymerase II promoter in response to stress; O-glycan processing; post-translational protein modification; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest. Disease: Medullary Cystic Kidney Disease 1

1 mg

565 USD