catalog number :
MBS531823
products full name :
TBG antibody
products short name :
TBG
products name syn :
Monoclonal TBG; Anti-TBG; T4 Binding Globulin; Thyroxine Binding Globulin; Anti TBG; TBG
other names :
thyroxine-binding globulin; Thyroxine-binding globulin; thyroxine-binding globulin; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7; Serpin A7; T4-binding globulin
other gene names :
SERPINA7; SERPINA7; TBG; TBG
uniprot entry name :
THBG_HUMAN
reactivity :
To be determined by end-user
purity :
> 90% pure. TBG antibody was purified by Protein A chromatography.
form :
Protein A purified and supplied in 10mM PBS, pH 7.2 with 0.1% NaN3.
concentration :
Typically ~ 5.0 mg/ml
storage stability :
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
tested application :
User optimized
other info1 :
Biological Significance: Thyroxine-binding globulin (TBG) binds thyroid hormone in circulation. It is one of three proteins (along with transthyretin and albumin) responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3?-triiodothyronine (T3) in the bloodstream. Of these three proteins, TBG has the highest affinity for T4 and T3, but is present in the lowest concentration. Despite its low concentration, TBG carries the majority of T4 in the blood.
other info2 :
Immunogen: TBG antibody was raised in mouse using purified human TBG as the immunogen.
products categories :
Hormones & Steroids
products description :
Mouse monoclonal TBG antibody
ncbi acc num :
NP_000345.2
ncbi gb acc num :
NM_000354.5
ncbi mol weight :
46,325 Da
ncbi summary :
There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012]