PPAR alpha antibody | MyBioSource MBS531794 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PPAR alpha antibody

catalog :

MBS531794

quantity :

0.1 mL

price :

780 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3B6

reactivity :

human, mouse, rat

application :

western blot, immunoprecipitation

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS531794

products type :

Antibody

products full name :

PPAR alpha antibody

products short name :

PPAR alpha

products name syn :

Monoclonal PPAR alpha; Anti-PPAR alpha; Anti PPAR alpha; PPAR alpha; Peroxisome Proliferator Activated Receptor alpha

other names :

peroxisome proliferator-activated receptor alpha; Peroxisome proliferator-activated receptor alpha; peroxisome proliferator-activated receptor alpha; peroxisome proliferator-activated receptor alpha; Nuclear receptor subfamily 1 group C member 1

products gene name :

PPAR alpha

other gene names :

PPARA; PPARA; PPAR; NR1C1; hPPAR; PPARalpha; NR1C1; PPAR; PPAR-alpha

uniprot entry name :

PPARA_HUMAN

clonality :

Monoclonal

isotype :

IgG2b

clone :

3B6

host :

Mouse

reactivity :

Human, Mouse, Rat

sequence length :

468

specificity :

Murine

form :

Purified IgG suopplied in PBS with 0.05% NaN3.

concentration :

1.0 mg/ml

storage stability :

Aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles.

tested application :

Gel Shift, Immunoprecipitation (IP), Western Blot (WB)

app notes :

WB: 2-5 ug/ml

other info1 :

Biological Significance: Peroxisome proliferators are carcinogens purported to exert their effect on cells through interaction with members of the nuclear hormone receptor family, the peroxisome proliferator activated receptors (PPARs).

other info2 :

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: PPAR Alpha antibody was raised in mouse using purified recombinant PPAR alpha protein as the immunogen.

products categories :

DNA & RNA

products description :

Mouse monoclonal PPAR alpha antibody

ncbi gi num :

50348666

ncbi acc num :

NP_001001928.1

ncbi gb acc num :

NM_001001928.2

uniprot acc num :

Q07869

ncbi mol weight :

18,942 Da

ncbi pathways :

Activation Of Gene Expression By SREBF (SREBP) Pathway (685552); Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); Adipogenesis Pathway (198832); BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway (477138); Circadian Clock Pathway (187173); Developmental Biology Pathway (477129); Energy Metabolism Pathway (198907); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); Gene Expression Pathway (105937)

ncbi summary :

Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]

uniprot summary :

PPAR-alpha: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. Belongs to the nuclear hormone receptor family. NR1 subfamily. Protein type: Nuclear receptor; DNA-binding. Chromosomal Location of Human Ortholog: 22q13.31. Cellular Component: nucleoplasm; nucleus. Molecular Function: protein domain specific binding; ligand-dependent nuclear receptor activity; NFAT protein binding; zinc ion binding; drug binding; phosphatase binding; protein binding; DNA binding; ubiquitin conjugating enzyme binding; sequence-specific DNA binding; protein complex binding; steroid hormone receptor activity; lipid binding; transcription factor activity. Biological Process: circadian rhythm; epidermis development; wound healing; positive regulation of transcription, DNA-dependent; heart development; behavioral response to nicotine; cellular lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter; fatty acid metabolic process; negative regulation of appetite; response to insulin stimulus; positive regulation of gluconeogenesis; negative regulation of blood pressure; circadian regulation of gene expression; negative regulation of protein binding; negative regulation of glycolysis; transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; lipoprotein metabolic process; regulation of circadian rhythm; positive regulation of fatty acid beta-oxidation; positive regulation of fatty acid oxidation; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; gene expression; steroid hormone mediated signaling; lipid metabolic process; fatty acid transport

size1 :

0.1 mL

price1 :

780 USD

more info or order :

MyBioSource product webpage