CD81 antibody | MyBioSource MBS531789 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

CD81 antibody

catalog :

MBS531789

quantity :

0.2 mg

price :

570 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1D6

reactivity :

human, chimpanzee

application :

western blot, immunohistochemistry, immunoprecipitation, flow cytometry, FACS, immunohistochemistry - paraffin section

product information

catalog number :

MBS531789

products type :

Antibody

products full name :

CD81 antibody

products short name :

CD81

products name syn :

Monoclonal CD81; Anti-CD81; CD 81; CD-81; TAPA-1; TAPA1; CD81

other names :

CD81 antigen isoform 1; CD81 antigen; CD81 antigen; CD81 molecule; 26 kDa cell surface protein TAPA-1; Target of the antiproliferative antibody 1; Tetraspanin-28; Tspan-28; CD_antigen: CD81

products gene name :

CD81

other gene names :

CD81; CD81; S5.7; CVID6; TAPA1; TSPAN28; TAPA1; TSPAN28; Tspan-28

uniprot entry name :

CD81_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

1D6

host :

Mouse

reactivity :

Chimpanzee, Goat, Sheep

sequence length :

236

specificity :

Human

purity :

CD81 antibody was purified by Protein G affinity chromatography.

form :

Purified IgG supplied in PBS, pH 7.4 with 0.09% NaN3.

storage stability :

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

tested application :

Flow Cytometry (FC/FACS), Immunohistochemistry (IHC) Paraffin, Immunoprecipitation (IP), Western Blot (WB)

app notes :

FC: 1:5-1:10

other info1 :

Biological Significance: CD81 (Cluster of Differentiation 81), is a protein which in humans is encoded by the CD81 gene. It is also known as 26 kDa cell surface protein, Target of the antiproliferative antibody 1 (TAPA-1) and Tetraspanin-28 (Tspan-28). CD81 is expressed in hemopoietic, endothelial and epithelial cells. It is absent from erythrocytes, platelets and neutrophils.

other info2 :

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling. Immunogen: CD81 antibody was raised in mouse using OCI-LY8 cells aggregated by another CD81 antibody as the immunogen.

products categories :

Cell Biology

products description :

Mouse monoclonal CD81 antibody

ncbi gi num :

4757944

ncbi acc num :

NP_004347.1

ncbi gb acc num :

NM_004356.3

uniprot acc num :

P60033

ncbi mol weight :

25,809 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); B Cell Receptor Signaling Pathway (198909); B Cell Receptor Signaling Pathway (83081); B Cell Receptor Signaling Pathway (492); Hepatitis C Pathway (173973); Hepatitis C Pathway (173907); Immune System Pathway (106386); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (106413); Malaria Pathway (152665); Malaria Pathway (152657)

ncbi summary :

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

uniprot summary :

CD81: May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV. Defects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6); also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. Belongs to the tetraspanin (TM4SF) family. Protein type: Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 11p15.5. Cellular Component: focal adhesion; membrane; integral to plasma membrane; plasma membrane; immunological synapse; vesicle. Molecular Function: protein binding. Biological Process: virion attachment, binding of host cell surface receptor; cell proliferation; regulation of immune response; protein localization; entry of virus into host cell; positive regulation of peptidyl-tyrosine phosphorylation; activation of MAPK activity; positive regulation of 1-phosphatidylinositol 4-kinase activity; positive regulation of cell proliferation; positive regulation of B cell proliferation; phosphatidylinositol biosynthetic process; phosphatidylinositol metabolic process. Disease: Immunodeficiency, Common Variable, 6

size1 :

0.2 mg

price1 :

570 USD