Filamin antibody | MyBioSource MBS531705 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Filamin antibody

catalog :

MBS531705

quantity :

0.1 mg

price :

430 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

PM6/317

reactivity :

human, rat, chicken

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS531705

products type :

Antibody

products full name :

Filamin antibody

products short name :

Filamin

products name syn :

Monoclonal Filamin; Anti-Filamin

other names :

filamin; Filamin-B; filamin-B; filamin B, beta; ABP-278; ABP-280 homolog; Actin-binding-like protein; Beta-filamin; Filamin homolog 1; Fh1; Filamin-3; Thyroid autoantigen; Truncated actin-binding protein; Truncated ABP

other gene names :

FLNB; FLNB; AOI; FH1; SCT; TAP; LRS1; TABP; FLN-B; FLN1L; ABP-278; ABP-280; FLN1L; FLN3; TABP; TAP; FLN-B; Fh1; Truncated ABP

uniprot entry name :

FLNB_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

PM6/317

host :

Mouse

reactivity :

Chicken, Guinea Pig, Human, Rabbit, Rat

sequence length :

2602

purity :

Filamin antibody was purified by affniity chromatography.

form :

Protein A purified and supplied in PBS with 1 mg/ml BSA, and 10mM NaN3.

concentration :

0.1 mg/ml

storage stability :

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

tested application :

Immunohistochemistry (IHC), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

app notes :

WB: 1:1,000-1:4,000

other info1 :

Biological Significance: Filamin is a structural protein that forms flexible cross-links between two actin filaments. Filamin is a homodimer of polypeptide chains each joined to the other at one end with an actin binding site ath the other. It is present in smooth muscle, fibroblasts, platelets and lymphocytes.

other info2 :

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling. Immunogen: Filamin antibody was raised in mouse using platelet filamin as the immunogen.

products categories :

Cancer

products description :

Mouse monoclonal Filamin antibody

ncbi gi num :

8100574

ncbi acc num :

AAF72339.1

uniprot acc num :

O75369

ncbi mol weight :

276,939 Da

ncbi pathways :

Antiviral Mechanism By IFN-stimulated Genes Pathway (530760); Cytokine Signaling In Immune System Pathway (366171); Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); ISG15 Antiviral Mechanism Pathway (530761); Immune System Pathway (106386); Interferon Signaling Pathway (187103); MAPK Signaling Pathway (83048); MAPK Signaling Pathway (456); Proteoglycans In Cancer Pathway (782000)

ncbi summary :

This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009]

uniprot summary :

FLNB: a ubiquitous cytoskeletal protein that links actin filaments to membrane glycoproteins. Six alternatively spliced isoforms have been described. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoforms 1 and 2 are expressed in placenta, bone marrow, brain, umbilical vein endothelial cells, retina and skeletal muscle. Isoform 1 is predominantly expressed in prostate, uterus, liver, thyroid, stomach, lymph node, small intestine, spleen, skeletal muscle, kidney, placenta, pancreas, heart, lung, platelets, endothelial cells, megakaryocytic and erythroleukemic cell lines. Isoform 2 is predominantly expressed in spinal cord and platelets. Also expressed in thyroid adenoma, neurofibrillary tangles (NFT), senile plaques in the hippocampus and cerebral cortex in Alzheimer s disease. Isoform 3 and isoform 6 are expressed predominantly in lung, heart, skeletal muscle, testis, spleen, thymus and leukocytes. Isoform 4 and isoform 5 are expressed in heart. Protein type: Actin-binding; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 3p14.3. Cellular Component: focal adhesion; cytoplasm; integral to membrane; stress fiber; plasma membrane; cell cortex; cytosol; Z disc; actin cytoskeleton. Molecular Function: identical protein binding; protein binding; actin binding. Biological Process: skeletal muscle development; cytoskeletal anchoring; cytokine and chemokine mediated signaling pathway; actin cytoskeleton organization and biogenesis; cell differentiation; signal transduction. Disease: Larsen Syndrome; Boomerang Dysplasia; Atelosteogenesis, Type I; Spondylocarpotarsal Synostosis Syndrome; Atelosteogenesis, Type Iii

size1 :

0.1 mg

price1 :

430 USD

more info or order :

MyBioSource product webpage