Plasminogen antibody | MyBioSource MBS531645 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Plasminogen antibody

catalog :

MBS531645

quantity :

1 mg

price :

360 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4D2

reactivity :

human

application :

ELISA, immunohistochemistry, enzyme immunoassay, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS531645

products type :

Antibody

products full name :

Plasminogen antibody

products short name :

Plasminogen

products name syn :

Monoclonal Plasminogen; Anti-Plasminogen

other names :

plasminogen; Plasminogen; plasminogen; plasminogen

other gene names :

PLG; PLG

uniprot entry name :

PLMN_HUMAN

clonality :

Monoclonal

isotype :

IgG2b

clone :

4D2

host :

Mouse

reactivity :

Human

sequence length :

810

purity :

Plasminogen antibody was purified by Ion exchange chromatography.

form :

PBS, pH 7.4, 0.1 % NaN3.

storage stability :

Store at 4 degree C.

tested application :

ELISA (EIA), Immunohistochemistry (IHC) Formalin/Paraffin

other info1 :

Biological Significance: Plasmin is released as a zymogen called plasminogen (PLG) from the liver into the circulation. Plasminogen is converted into active plasmin by a variety of enzymes, including tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), kallikrein, and factor XII (Hageman factor). Fibrin is a cofactor for plasminogen activation by tissue plasminogen activator.

other info2 :

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: Plasminogen antibody was raised in mouse using human plasminogen as the immunogen.

products categories :

Proteases, Inhibitors, & Enzymes

products description :

Mouse monoclonal Plasminogen antibody

ncbi gi num :

387026

ncbi acc num :

AAA60113.1

uniprot acc num :

P00747

ncbi mol weight :

90,569 Da

ncbi pathways :

Activation Of Matrix Metalloproteinases Pathway (576264); Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); Blood Clotting Cascade Pathway (198840); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Degradation Of The Extracellular Matrix Pathway (576263); Dissolution Of Fibrin Clot Pathway (106061); Extracellular Matrix Organization Pathway (576262); Hemostasis Pathway (106028)

ncbi summary :

The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009]

uniprot summary :

Plasminogen: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. Defects in PLG are the cause of plasminogen deficiency (PLGD). PLGD is characterized by decreased serum plasminogen activity. Two forms of the disorder are distinguished: type 1 deficiency is additionally characterized by decreased plasminogen antigen levels and clinical symptoms, whereas type 2 deficiency, also known as dysplasminogenemia, is characterized by normal, or slightly reduced antigen levels, and absence of clinical manifestations. Plasminogen deficiency type 1 results in markedly impaired extracellular fibrinolysis and chronic mucosal pseudomembranous lesions due to subepithelial fibrin deposition and inflammation. The most common clinical manifestation of type 1 deficiency is ligneous conjunctivitis in which pseudomembranes formation on the palpebral surfaces of the eye progresses to white, yellow-white, or red thick masses with a wood-like consistency that replace the normal mucosa. Belongs to the peptidase S1 family. Plasminogen subfamily. Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; EC 3.4.21.7; Protease; Secreted. Chromosomal Location of Human Ortholog: 6q26. Cellular Component: extracellular space; cell surface; extrinsic to external side of plasma membrane; extracellular region; plasma membrane. Molecular Function: protein domain specific binding; protein binding; serine-type peptidase activity; serine-type endopeptidase activity; apolipoprotein binding; receptor binding. Biological Process: platelet activation; extracellular matrix organization and biogenesis; tissue remodeling; myoblast differentiation; muscle maintenance; extracellular matrix disassembly; negative regulation of cell proliferation; fibrinolysis; negative regulation of fibrinolysis; platelet degranulation; cellular protein metabolic process; proteolysis involved in cellular protein catabolic process; tissue regeneration; positive regulation of fibrinolysis; blood coagulation; transmembrane transport. Disease: Plasminogen Deficiency, Type I

size1 :

1 mg

price1 :

360 USD

more info or order :

MyBioSource product webpage