phospho MBP antibody | MyBioSource MBS531609 product information

product summary

request information :

company name :

MyBioSource

product type :

antibody

product name :

phospho MBP antibody

catalog :

MBS531609

quantity :

0.1 mg

price :

560 USD

clonality :

monoclonal

host :

mouse

reactivity :

rat

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS531609

products type :

Antibody

products full name :

phospho MBP antibody

products short name :

phospho MBP

products name syn :

Monoclonal phospho MBP; Anti-phospho MBP; Anti phospho MBP; Phosphorylated Myelin Basic Protein; phospho Myelin Basic Protein; pMBP; pMBP; Phosphorylated Myelin Basic Protein; phospho MBP; phospho Myelin Basic Protein

other names :

myelin basic protein isoform 4; Myelin basic protein S; Golli-Mbp; myelin basic protein; MBP S; myelin basic protein S; myelin basic protein Golli-mbp; Golli-Mbp; myelin basic protein; myelin basic protein S; myelin basic protein; N/A

other gene names :

Mbp; Mbp; Mbps; MBP S

uniprot entry name :

MBP_RAT

clonality :

Monoclonal

isotype :

IgG

clone :

P12

host :

Mouse

reactivity :

Vertebrates

specificity :

Human

purity :

phospho MBP antibody was purified by Protein G chromatography.

form :

Protein A purified antibody supplied in PBS, pH 7.4, with 30% glycerol, and 0.09% NaN3.

storage stability :

Aliquot and store at -20 deg C. Avoid repeated Freeze/Thaw cycles

tested application :

Kinase Assay, Western Blot (WB)

other info1 :

Immunogen: Phospho MBP antibody was raised in mouse using a sythetic peptide corresponding to the human myelin basic protein sequence phosphorylated at Thr98 and coupled to tuberculin as the immunogen.

other info2 :

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.

products categories :

Neuroscience; Monoclonal Antibodies

products description :

Mouse monoclonal phospho MBP antibody. Myelin basic protein (MBP) is the major extrinsic membrane protein of central nervous system and has a molecular mass of 21.5 kDa. MBP is believed to be important in the process of myelination of nerves in the central nervous system (CNS). The gene for MBP is on chromosome 18; the protein localizes to the CNS and to various cells of the hematopoietic system.

ncbi gi num :

70166270

ncbi acc num :

NP_001020465.1

ncbi gb acc num :

NM_001025294.1

uniprot acc num :

P02688

ncbi mol weight :

33 kDa (predicted detection band MW)

ncbi pathways :

MAPK Cascade Pathway 198535

ncbi summary :

The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called "Golli-Mbp") that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the 'shiverer' and 'myelin deficient' phenotypes in mouse. [provided by RefSeq, Jul 2008]

uniprot summary :

Function: Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane . By similarity. Subunit structure: Homodimer . By similarity. Subcellular location: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note: Cytoplasmic side of myelin. Tissue specificity: Found in both the central and the peripheral nervous system. Post-translational modification: As in other animals, several charge isomers may be produced as a result of optional post-translatonial modifications, such as phosphorylation of serine or threonine residues, deamidation of glutamine or asparagine residues, citrullination and methylation of arginine residues.Arg-131 was found to be 44% monomethylated and 11% symmetrically dimethylated.Phosphorylated by TAOK2, VRK2, MAPK11, MAPK12, MAPK14 and MINK1 . By similarity. Ref.10. Sequence similarities: Belongs to the myelin basic protein family.

size :

0.1 mg

price :

560 USD

more info or order :

MyBioSource product webpage