antibody

CD8a antibody (PE)

MBS531568

0.1 mg

190 USD

monoclonal

rat

PE

53-6.7

immunohistochemistry, flow cytometry, FACS

Antibody

CD8a antibody (PE)

CD8a

Monoclonal CD8a; Anti-CD8a; Ly2; CD-8a; CD 8a; CD8a

CD8a molecule; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 alpha chain; CD8a molecule; T-lymphocyte differentiation antigen T8/Leu-2; CD_antigen: CD8a

CD8a

CD8A; CD8A; CD8; MAL; p32; Leu2; MAL

CD8A_HUMAN

Monoclonal

IgG2a

53-6.7

Rat

To be determined by end-user

235

Murine CD8a

Supplied as a liquid in PBS, with NaN3 added as preservative.

0.1 mg/ml

Store at 4 degree C.

Flow Cytometry (FC/FACS), Immunohistochemistry (IHC)

Biological Significance: CD8a (Cluster of Differentiation 8a), is a human gene. The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Two alternative transcripts encoding distinct isoforms, one membrane associated and one secreted, have been identified.

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Tag/Conjugate: PE. Immunogen: CD8a antibody (FITC) was raised in rat using mouse thymus or spleen as the immunogen.

Immunology; Conjugated Monoclonal Antibodies

Rat monoclonal CD8a antibody (PE)

19344022

AAH25715.1

P01732

30,214 Da

Adaptive Immune System Pathway 366160!!Antigen Processing And Presentation Pathway 83074!!Antigen Processing And Presentation Pathway 485!!Cell Adhesion Molecules (CAMs) Pathway 83069!!Cell Adhesion Molecules (CAMs) Pathway 480!!Downstream Signaling In Naive CD8+ T Cells Pathway 138018!!Hematopoietic Cell Lineage Pathway 83078!!Hematopoietic Cell Lineage Pathway 489!!IL12-mediated Signaling Events Pathway 137922!!Immune System Pathway 106386

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

0.1 mg

190 USD