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company name :
MyBioSource
product type :
antibody
product name :
Mannose 6-Phosphate Receptor antibody
catalog :
MBS531543
quantity :
0.1 mg
price :
745 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2G11
reactivity :
human, rat
application :
western blot, immunocytochemistry, immunoprecipitation
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS531543
products type :
Antibody
products full name :
Mannose 6-Phosphate Receptor antibody
products short name :
Mannose 6-Phosphate Receptor
products name syn :
Monoclonal Mannose 6-Phosphate Receptor; Anti-Mannose 6-Phosphate Receptor; Mannose-Phosphate Receptor-6; Mannose 6-Phosphate Receptor; Mannose-Phosphate Receptor 6; Late Endosome Marker; Mannose 6 Phosphate Receptor (Cation independent)
other names :
mannose 6-phosphate receptor; Cation-independent mannose-6-phosphate receptor; cation-independent mannose-6-phosphate receptor; insulin-like growth factor 2 receptor; 300 kDa mannose 6-phosphate receptor; MPR 300; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; IGF-II receptor; M6P/IGF2 receptor; M6P/IGF2R; CD_antigen: CD222
other gene names :
IGF2R; IGF2R; MPR1; MPRI; CD222; CIMPR; M6P-R; MPRI; CI Man-6-P receptor; CI-MPR; M6PR; MPR 300; IGF-II receptor; M6P/IGF2R
uniprot entry name :
MPRI_HUMAN
clonality :
Monoclonal
isotype :
IgG2a
clone :
2G11
host :
Mouse
reactivity :
Human, Non-Human Primate, Rat
sequence length :
2491
specificity :
Bovine
form :
PBS solution containing 0.05% NaN3
concentration :
1.0 mg/ml
storage stability :
Aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles.
tested application :
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB)
app notes :
ICC: 2-5 ug/ml. IF: 2-5 ug/ml. WB: 1 ug/ml
other info1 :
Biological Significance: Lysosomal enzymes containing one or two mannose 6-phosphate (man6P) moieties are moved about in the cell by means of ~300 kDa cation independent mannose 6-phospate receptors (CI-MPR). In addition to its man6P binding activity, the MPR contains a separate binding site for the type II insulin-like growth factor and is capable of binding both man6P and IGF-II simultaneously. An ~240 kDa soluble, truncated form, representing the extracellular domain of the protein, has also been found circulating in serum and is capable of binding both ligands.
other info2 :
Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: Mannose 6-phosphate receptor antibody was raised in mouse using purified Bovine 300 kDa CI-MPR. as the immunogen.
products categories :
Cell Biology
products description :
Mouse monoclonal Mannose 6-Phosphate Receptor antibody
ncbi gi num :
188672
ncbi acc num :
AAA59866.1
uniprot acc num :
P11717
ncbi mol weight :
274,375 Da
ncbi pathways :
Clathrin Derived Vesicle Budding Pathway 119545!!Golgi Associated Vesicle Biogenesis Pathway 119546!!Lysosome Pathway 99052!!Lysosome Pathway 96865!!Membrane Trafficking Pathway 106160!!Vesicle-mediated Transport Pathway 1183600!!Trans-Golgi Network Vesicle Budding Pathway 106165
ncbi summary :
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. While the related mouse gene shows exclusive expression from the maternal allele, imprinting of the human gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele. [provided by RefSeq, Apr 2013]
size :
0.1 mg
price :
745 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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