Desmoplakin 1 + 2 antibody | MyBioSource MBS531517 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Desmoplakin 1 + 2 antibody

catalog :

MBS531517

quantity :

0.05 mg

price :

395 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

DP 1 + 2-2.15

reactivity :

human, mouse, rat, chicken, cow

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS531517

products type :

Antibody

products full name :

Desmoplakin 1 + 2 antibody

products short name :

Desmoplakin 1 + 2

products name syn :

Monoclonal Desmoplakin 1 + 2; Anti-Desmoplakin 1 + 2; Desmoplakin 1/2

other names :

desmoplakin isoform I; Desmoplakin; desmoplakin; desmoplakin; 250/210 kDa paraneoplastic pemphigus antigen

other gene names :

DSP; DSP; DP; DPI; DPII; DCWHKTA; DP

uniprot entry name :

DESP_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

DP 1 + 2-2.15

host :

Mouse

reactivity :

Bovine, Chicken, Human, Mouse, Rat

sequence length :

2871

specificity :

Bovine desmoglein 1/2

purity :

Protein A affinity chromatography

form :

Supplied as a lyophilized powder. Reconstitute in 1 ml dist. water (final solution contains 0.09 % NaN3, 0.5% BSA in PBS buffer, pH 7.4)

storage stability :

Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze-thaw cycles.

tested application :

Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin, Western Blot (WB)

app notes :

IHC-F: 1:10

other info1 :

Biological Significance: Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin.

other info2 :

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: Desmoplakin 1/2 antibody was raised in mouse using bovine desmoplakin 1&2 as the immunogen.

products categories :

Cell Biology

products description :

Mouse monoclonal Desmoplakin 1 + 2 antibody

ncbi gi num :

58530840

ncbi acc num :

NP_004406.2

ncbi gb acc num :

NM_004415.2

uniprot acc num :

P15924

ncbi mol weight :

278,916 Da

ncbi pathways :

Alpha6-Beta4 Integrin Signaling Pathway (198807); Apoptosis Pathway (105648); Apoptotic Cleavage Of Cell Adhesion Proteins Pathway (105680); Apoptotic Cleavage Of Cellular Proteins Pathway (105678); Apoptotic Execution Phase Pathway (105677); Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Programmed Cell Death Pathway (1127510)

ncbi summary :

Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. [provided by RefSeq, Jul 2008]

uniprot summary :

Desmoplakin: Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. Homodimer. Interacts with COL17A1 (via cytoplasmic region). Associates (via C-terminal) with KRT5-KRT14 (via rod region), KRT8-KRT18 and VIM intermediate filaments. Interacts with DSC2. Isoform DPI is apparently an obligate constituent of all desmosomes. Isoform DPII resides predominantly in tissues and cells of stratified origin. Belongs to the plakin or cytolinker family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 6p24. Cellular Component: desmosome; mitochondrion; basolateral plasma membrane; plasma membrane; intermediate filament; cornified envelope; fascia adherens; nucleus. Molecular Function: protein binding, bridging; protein binding; protein kinase C binding; structural constituent of cytoskeleton; cell adhesion molecule binding; structural molecule activity. Biological Process: keratinocyte differentiation; cell-cell adhesion; epidermis development; wound healing; apoptosis; intermediate filament organization; peptide cross-linking; cell structure disassembly during apoptosis. Disease: Cardiomyopathy, Dilated, With Woolly Hair And Keratoderma; Arrhythmogenic Right Ventricular Dysplasia, Familial, 8; Keratosis Palmoplantaris Striata Ii; Cardiomyopathy, Dilated, With Woolly Hair, Keratoderma, And Tooth Agenesis; Skin Fragility-woolly Hair Syndrome; Epidermolysis Bullosa, Lethal Acantholytic

size1 :

0.05 mg

price1 :

395 USD

more info or order :

MyBioSource product webpage