catalog number :
MBS531456
products full name :
Calbindin antibody (D28K)
products short name :
Calbindin
products name syn :
Monoclonal Calbindin (D28K); Anti-Calbindin (D28K); Calbindin D28; CALB1; CAB27; CALB 1; D 28K; Calbindin 1 28kDa; CALB; D28K; Neuronal Marker
other names :
calbindin; Calbindin; calbindin; calbindin 1, 28kDa; Calbindin D28; D-28K; Vitamin D-dependent calcium-binding protein, avian-type
other gene names :
CALB1; CALB1; CALB; D-28K; CAB27
uniprot entry name :
CALB1_HUMAN
reactivity :
Chicken, Guinea Pig, Human, Monkey, Rabbit, Rat
specificity :
Chicken calbindin
form :
Supplied as a lyophilized powder
storage stability :
Store at 4 degree C for short term storage. Aliquot and store at -80 degree C for long term storage. Avoid repeated freeze/thaw cycles.
tested application :
Immunohistochemistry (IHC), Western Blot (WB)
app notes :
IHC: 1:2,000-1:5,000. WB: 1:1,000-1:2,000
other info1 :
Biological Significance: Calbindin is a calcium-binding protein belonging to the troponin C superfamily. It was originally described as a 27-kDa protein induced by vitamin D in the duodenum of the chick. In the brain, its synthesis is independent of vitamin-D-derived hormones. Calbindin contains 4 active calcium-binding domains, and 2 modified domains that presumably have lost their calcium-binding capacity.
other info2 :
Immunogen: Calbindin antibody (D28K) was raised in mouse using calbindin D-28k as the immunogen.
products categories :
Nutrition & Metabolism
products description :
Mouse monoclonal Calbindin antibody (D28K)
ncbi acc num :
NP_004920.1
ncbi gb acc num :
NM_004929.2
ncbi mol weight :
23,609 Da
ncbi pathways :
Endocrine And Other Factor-regulated Calcium Reabsorption Pathway 213307!!Endocrine And Other Factor-regulated Calcium Reabsorption Pathway 213276
ncbi summary :
The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability. This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease. [provided by RefSeq, Jan 2015]