Complement C1q antibody | MyBioSource MBS531348 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Complement C1q antibody

catalog :

MBS531348

quantity :

0.05 mg

price :

420 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

242G3

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS531348

products type :

Antibody

products full name :

Complement C1q antibody

products short name :

Complement C1q

products name syn :

Monoclonal Complement C1q; Anti-Complement C1q; C1q; Complement C1q; Complement Cq 1; Complement Cq -1

other names :

complement C1q subcomponent subunit B; Complement C1q subcomponent subunit B; complement C1q subcomponent subunit B; complement component 1, q subcomponent, B chain

other gene names :

C1QB; C1QB

uniprot entry name :

C1QB_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

242G3

host :

Mouse

reactivity :

Human

sequence length :

253

specificity :

Human complement C1q

purity :

Protein A affinity chromatography

form :

Lyophilized. Reconstitute in 1 ml dist. water (final solution contains 0.09 % NaN3, 0.5% BSA in PBS buffer, pH 7.4)

storage stability :

Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze-thaw cycles.

tested application :

ELISA (EIA), Inhibition, Western Blot (WB)

app notes :

WB: 1:100

other info1 :

Biological Significance: The C1q complex is potentially multivalent for attachment to the complement fixation sites of immunoglobulin. The sites are on the CH2 domain of IgG and probably on the CH4 domain of IgM. The appropriate peptide sequence of the complement fixing site might become exposed following complexing of the immunoglobulin, or the sites might always be available, but might require multiple attachment by C1q with critical geometry in order to achieve the necessary avidity.

other info2 :

Immunogen: Complement C1q antibody was raised in mouse using human complement C1q as the immunogen.

products categories :

Immunology

products description :

Mouse monoclonal Complement C1q antibody

ncbi gi num :

87298828

ncbi acc num :

NP_000482.3

ncbi gb acc num :

NM_000491.3

uniprot acc num :

P02746

ncbi mol weight :

26,722 Da

ncbi pathways :

Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Classical Antibody-mediated Complement Activation Pathway (106409); Complement Activation, Classical Pathway (198823); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (106405); Creation Of C4 And C2 Activators Pathway (106407); Immune System Pathway (106386)

ncbi summary :

This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the B-chain polypeptide of human complement subcomponent C1q [provided by RefSeq, Jul 2008]

uniprot summary :

C1QB: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Defects in C1QB are a cause of complement component C1q deficiency (C1QD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 1p36.12. Cellular Component: collagen; extracellular region; complement component C1 complex. Molecular Function: protein binding; protein homodimerization activity. Biological Process: innate immune response; complement activation, classical pathway; inner ear development; complement activation. Disease: C1q Deficiency

size1 :

0.05 mg

price1 :

420 USD

more info or order :

MyBioSource product webpage