antibody

ACE antibody

MBS531334

0.1 mg

655 USD

monoclonal

mouse

nonconjugated

9B9

human, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, enzyme immunoassay

Antibody

ACE antibody

ACE

Monoclonal ACE; Anti-ACE; Angiotensin Converting Enzyme; CD143

Angiotensin-converting enzyme; Angiotensin-converting enzyme; angiotensin-converting enzyme; angiotensin I converting enzyme; Dipeptidyl carboxypeptidase I; Kininase II; CD_antigen: CD143

ACE

ACE; ACE; DCP; ICH; ACE1; DCP1; CD143; MVCD3; DCP; DCP1; ACE

ACE_HUMAN

Monoclonal

IgG1

9B9

Mouse

Cat, Hamster, Monkey, Rat

1306

Human

PBS, pH 7.4, with 150mM NaCl and 0.05% NaN3.

Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles

ELISA (EIA), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin, Immunoprecipitation (IP), Western Blot (WB)

ELISA: 1:1,000. ICC: 1:100. IHC-F: 1:1,000. IP: 1:1,000-1:10,000. WB: 1:100

Biological Significance: Angiotensin I-converting enzyme an exopeptidase, is a circulating enzyme that participates in the body's renin-angiotensin system (RAS), which mediates extracellular volume (i.e. that of the blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. It is secreted by pulmonary and renal endothelial cells and catalyzes the conversion of decapeptide angiotensin I to octapeptide angiotensin II.

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling. Immunogen: ACE antibody was raised in mouse using ACE from human lung as the immunogen.

Proteases, Inhibitors, & Enzymes

Mouse monoclonal ACE antibody

113045

P12821.1

P12821

78,694 Da

ACE Inhibitor Pathway 198763!!Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Hypertrophic Cardiomyopathy (HCM) Pathway 114229!!Hypertrophic Cardiomyopathy (HCM) Pathway 106591!!Metabolism Of Angiotensinogen To Angiotensins Pathway 685555!!Metabolism Of Proteins Pathway 106230!!Peptide Hormone Metabolism Pathway 771603!!Renin-angiotensin System Pathway 83075!!Renin-angiotensin System Pathway 486

This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]

0.1 mg

655 USD