MyBioSource

antibody

Troponin I antibody (Cardiac)

MBS531323

1 mg

560 USD

monoclonal

mouse

dog

ELISA, immunoprecipitation, western blot, enzyme immunoassay, immunohistochemistry

MBS531323

Antibody

Troponin I antibody (Cardiac)

Troponin I (Cardiac)

Monoclonal Troponin I (Cardiac); Anti-Troponin I (Cardiac)

troponin I, cardiac muscle; Troponin I, cardiac muscle; troponin I, cardiac muscle; cardiac troponin I; Cardiac troponin I

TNNI3; TNNI3; N/A

TNNI3_CANFA

Monoclonal

IgG1

M8030409

Mouse

Human

Troponin I antibody (Cardiac) was purified by chromatography on protein A Sepharose.

Protein A purified IgG supplied in PBS, pH 7.4, 0.1 % NaN3.

Store at 4 deg C.

ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)

Matched pair antibody available for Troponin I antibody (Cardiac) : 10-T79C

Immunogen: Troponin I antibody (cardiac) was raised in mouse using animo acid residues 86-90 of cTnI as the immunogen.

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.

Cardiac Markers; Monoclonal Antibodies

Mouse monoclonal Troponin I antibody (Cardiac) . Human troponin I is presented in cardiac muscle tissue by a single isoform with molecular weight 23876 Da and it consists of 209 amino acid residues. cTnI molecule contains two serines in the 22 and 23 positions. Both amino acid residues can be phosphorylated in vivo by protein kinase A, so four forms of protein - one dephospho, two monophospho and one bisphospho - can coexist in the cell.

50978684

NP_001003041.1

NM_001003041.1

Q8MKD5

23,912 Da

Cardiac Muscle Contraction Pathway 93348!!Cardiac Muscle Contraction Pathway 93992!!Dilated Cardiomyopathy Pathway 121497!!Dilated Cardiomyopathy Pathway 121285!!Hypertrophic Cardiomyopathy (HCM) Pathway 114402!!Hypertrophic Cardiomyopathy (HCM) Pathway 106591!!Muscle Contraction Pathway 580369!!Striated Muscle Contraction Pathway 580370

Function: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity . By similarity. Subunit structure: Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1 . By similarity. Post-translational modification: Phosphorylated at Ser-23 and Ser-24 by PRKD1; phosphorylation reduces myofilament calcium sensitivity. Phosphorylated preferentially at Thr-32. Phosphorylation by STK4/MST1 alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T).Phosphorylated at Ser-43 and Ser-45 by PRKCE; phosphorylation increases myocardium contractile dysfunction . By similarity. Sequence similarities: Belongs to the troponin I family.

1 mg

560 USD