catalog number :
MBS531293
products full name :
Plakophilin 2 antibody (2a + 2b)
products short name :
Plakophilin 2
products name syn :
Monoclonal Plakophilin 2 (2a + 2b); Anti-Plakophilin 2 (2a + 2b); Anti Plakophilin 2 (2a + 2b); Plakophilin 2 (2a + 2b); Plakophilin 2a + 2b
other names :
plakophilin-2 isoform 2b; Plakophilin-2; plakophilin-2; plakophilin 2
other gene names :
PKP2; PKP2; ARVD9
uniprot entry name :
PKP2_HUMAN
reactivity :
Bovine, Dog, Frog, Human, Mouse, Rat
specificity :
Human plakophilin 2
purity :
Culture supernatant
form :
Supplied as a liquid with 0.09% NaN3
storage stability :
Store at 4 degree C.
tested application :
Immunohistochemistry (IHC) Formalin/Paraffin, Immunoprecipitation (IP), Western Blot (WB)
other info1 :
Biological Significance: Plakophilin-2 is a protein that in humans is encoded by the PKP2 gene. This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton.
other info2 :
Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: Plakophilin 2 antibody (2a+2b) was raised in mouse using a synthetic carboxyterminal peptide of human plakophilin 2 as the immunogen.
products categories :
Cancer
products description :
Mouse monoclonal Plakophilin 2 antibody (2a + 2b)
ncbi acc num :
NP_004563.2
ncbi gb acc num :
NM_004572.3
ncbi mol weight :
92,756 Da
ncbi pathways :
Arrhythmogenic Right Ventricular Cardiomyopathy Pathway 672454!!Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway 117293!!Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway 116129
ncbi summary :
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. [provided by RefSeq, Jul 2008]