IGF2 antibody | MyBioSource MBS531250 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

IGF2 antibody

catalog :

MBS531250

quantity :

0.1 mg

price :

550 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

W2H1

reactivity :

human

application :

ELISA, immunohistochemistry, radioimmunoassay, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS531250

products type :

Antibody

products full name :

IGF2 antibody

products short name :

IGF2

products name syn :

Monoclonal IGF2; Anti-IGF2; IGF 2; IGF-2; IGF-II; Insulin Growth Factor 2; IGF2

other names :

insulin-like growth factor II; Insulin-like growth factor II; insulin-like growth factor II; insulin-like growth factor 2; Somatomedin-A; T3M-11-derived growth factor

products gene name :

IGF2

other gene names :

IGF2; IGF2; IGF-II; PP9974; C11orf43; IGF-II

uniprot entry name :

IGF2_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

W2H1

host :

Mouse

reactivity :

Human

sequence length :

180

purity :

IGF2 antibody was purified by affinity chromatography.

form :

PBS with 0.09% NaN3.

concentration :

0.1 mg/ml

storage stability :

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

tested application :

ELISA (EIA), Immunohistochemistry (IHC), Radioimmunoassay (RIA)

other info1 :

Biological Significance: Insulin-like growth factor 2 (IGF-2) is one of three protein hormones that share structural similarity to insulin. IGF-2 exerts its effects by binding to the IGF-1 receptor. The major role of IGF2 is as a growth promoting hormone during gestation. In the process of Folliculogenesis, IGF2 is created by Theca cells to act in an autocrine manner on the theca cells themselves, and in a paracrine manner on Granulosa cells in the ovary.

other info2 :

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling. Immunogen: IGF2 antibody was raised in mouse using human anti-globulin conjugated to IGF-II as the immunogen.

products categories :

Hormones & Steroids

products description :

Mouse monoclonal IGF2 antibody

ncbi gi num :

189955

ncbi acc num :

AAA60088.1

uniprot acc num :

P01344

ncbi mol weight :

26,331 Da

ncbi pathways :

Apoptosis Pathway (198797); Cardiac Progenitor Differentiation Pathway (712094); Endochondral Ossification Pathway (198812); Hedgehog Signaling Pathway (198835); Hemostasis Pathway (106028); IGF1R Signaling Cascade Pathway (730346); IRS-related Events Triggered By IGF1R Pathway (730348); Metabolism Of Proteins Pathway (106230); Platelet Activation, Signaling And Aggregation Pathway (106034); Platelet Degranulation Pathway (106050)

ncbi summary :

This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

uniprot summary :

IGF2: The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development. Epigenetic changes of DNA hypomethylation in IGF2 are a cause of Silver-Russell syndrome (SRS). A clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations. The phenotypic expression changes during childhood and adolescence, with the facial features and asymmetry usually becoming more subtle with age. Belongs to the insulin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 11p15.5. Cellular Component: extracellular space; extracellular region; plasma membrane. Molecular Function: protein serine/threonine kinase activator activity; insulin-like growth factor receptor binding; protein binding; growth factor activity; hormone activity; receptor activator activity; insulin receptor binding. Biological Process: positive regulation of catalytic activity; response to nicotine; genetic imprinting; multicellular organismal development; positive regulation of glycogen biosynthetic process; exocrine pancreas development; female pregnancy; positive regulation of activated T cell proliferation; response to estradiol stimulus; response to radiation; platelet degranulation; regulation of transcription, DNA-dependent; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; skeletal development; response to nutrient levels; response to drug; platelet activation; positive regulation of mitosis; glucose metabolic process; memory; osteoblast differentiation; positive regulation of protein kinase B signaling cascade; positive regulation of peptidyl-tyrosine phosphorylation; organ morphogenesis; response to ethanol; cellular protein metabolic process; insulin receptor signaling pathway; striated muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of insulin receptor signaling pathway; positive regulation of protein amino acid phosphorylation; blood coagulation. Disease: Silver-russell Syndrome; Growth Restriction, Severe, With Distinctive Facies; Beckwith-wiedemann Syndrome; Wilms Tumor 1

size1 :

0.1 mg

price1 :

550 USD

more info or order :

MyBioSource product webpage