Lipoprotein Lipase antibody | MyBioSource MBS531173 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Lipoprotein Lipase antibody

catalog :

MBS531173

quantity :

0.05 mg

price :

430 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

Mab-7

reactivity :

human, cow

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS531173

products type :

Antibody

products full name :

Lipoprotein Lipase antibody

products short name :

Lipoprotein Lipase

products name syn :

Monoclonal Lipoprotein Lipase; Anti-Lipoprotein Lipase

other names :

lipoprotein lipase; Lipoprotein lipase; lipoprotein lipase; lipoprotein lipase

other gene names :

LPL; LPL; LIPD; HDLCQ11; LIPD; LPL

uniprot entry name :

LIPL_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

Mab-7

host :

Mouse

reactivity :

Bovine, Human

sequence length :

475

specificity :

Bovine lipoprotein lipase

purity :

Protein A affinity chromatography

form :

Lyophilized. Reconstitute in 1 ml dist. water (final solution contains 0.09 % NaN3, 0.5% BSA in PBS buffer, pH 7.4)

storage stability :

Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze-thaw cycles.

tested application :

User optimized

other info1 :

Biological Significance: Lipoprotein lipase is an enzyme that hydrolyzes lipids in lipoproteins, such as those found in chylomicrons and very low-density lipoproteins (VLDL), into three free fatty acids and one monoacylglycerol molecule. It requires Apo-CII as a cofactor. Lipoprotein lipase is specifically found in endothelial cells lining the capillaries.

other info2 :

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: Lipoprotein lipase antibody was raised in mouse using purified bovine lipoprotein lipase as the immunogen.

products categories :

Proteases, Inhibitors, & Enzymes

products description :

Mouse monoclonal Lipoprotein Lipase antibody

ncbi gi num :

4557727

ncbi acc num :

NP_000228.1

ncbi gb acc num :

NM_000237.2

uniprot acc num :

P06858

ncbi mol weight :

53,162 Da

ncbi pathways :

Adipogenesis Pathway (198832); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Chylomicron-mediated Lipid Transport Pathway (106157); Developmental Biology Pathway (477129); Fatty Acid Beta Oxidation Pathway (198865); Glycerolipid Metabolism Pathway (82986); Glycerolipid Metabolism Pathway (361); Lipid Digestion, Mobilization, And Transport Pathway (106111)

ncbi summary :

LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008]

uniprot summary :

LPL: The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium. Defects in LPL are the cause of lipoprotein lipase deficiency (LPL deficiency); also known as familial chylomicronemia or hyperlipoproteinemia type I. LPL deficiency chylomicronemia is a recessive disorder usually manifesting in childhood. On a normal diet, patients often present with abdominal pain, hepatosplenomegaly, lipemia retinalis, eruptive xanthomata, and massive hypertriglyceridemia, sometimes complicated with acute pancreatitis. Belongs to the AB hydrolase superfamily. Lipase family. Protein type: Lipid Metabolism - glycerolipid; Membrane protein, GPI anchor; Phospholipase; EC 3.1.1.34. Chromosomal Location of Human Ortholog: 8p22. Cellular Component: extracellular matrix; extracellular space; chylomicron; cell surface; extracellular region; plasma membrane. Molecular Function: heparin binding; triacylglycerol lipase activity; protein binding; lipoprotein lipase activity; apolipoprotein binding; phospholipase activity; triglyceride binding; receptor binding. Biological Process: response to drug; phototransduction, visible light; triacylglycerol metabolic process; phospholipid metabolic process; triacylglycerol catabolic process; lipoprotein metabolic process; triacylglycerol biosynthetic process; response to cold; retinoid metabolic process; fatty acid biosynthetic process. Disease: Hyperlipoproteinemia, Type I; Hyperlipidemia, Familial Combined

size1 :

0.05 mg

price1 :

430 USD

more info or order :

MyBioSource product webpage