catalog number :
MBS531126
products full name :
TSH beta antibody
products short name :
TSH beta
products name syn :
Monoclonal TSH beta; Anti-TSH beta; TSHB; Thyrotropin beta subunit; Thyrotropin beta chain precursor; Thyroid stimulating hormone beta precursor; TSH beta; Thyroid stimulating hormone beta subunit; CHNG4; Anti TSH beta
other names :
thyrotropin subunit beta; Thyrotropin subunit beta; thyrotropin subunit beta; thyroid stimulating hormone, beta; Thyroid-stimulating hormone subunit beta; TSH-B; TSH-beta; Thyrotropin beta chain
products gene name :
TSH beta
other gene names :
Tshb; Tshb; TSH-B; TSH-beta
uniprot entry name :
TSHB_RAT
reactivity :
To be determined by end-user
purity :
> 95% pure. Chromatographically purified (S-200, DEAE) immunoglobulin fraction
form :
Chromatographically purified IgG fraction supplied in 50mM PBS buffer, pH 7.4 with 0.1% NaN3.
storage stability :
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
tested application :
User optimized
app notes :
Matched pair antibody available for TSH beta antibody: MBS531703
other info1 :
Biological Significance: Thyroid stimulating hormone (TSH) is a peptide hormone synthesized and secreted by thyrotrope cells in the anterior pituitary gland, which regulates the endocrine function of the thyroid gland. TSH is a glycoprotein that consists of alpha and beta subunits. The ? subunit is thought to be the effector region responsible for stimulation of adenylate cyclase (involved the generation of cAMP). The ? (beta) subunit (TSHB) is unique to TSH, and therefore determines its receptor specificity.
other info2 :
Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Affinity Constant: 2 x 10^10 l/mol. Immunogen: TSH beta antibody was raised in mouse using human TSH beta as the immunogen.
products categories :
Hormones & Steroids
products description :
Mouse monoclonal TSH beta antibody
ncbi acc num :
NP_037248.2
ncbi gb acc num :
NM_013116.2
ncbi mol weight :
15,505 Da
ncbi pathways :
Amine-derived Hormones Pathway 1178245!!Autoimmune Thyroid Disease Pathway 83509!!Autoimmune Thyroid Disease Pathway 533!!Class A/1 (Rhodopsin-like Receptors) Pathway 1177697!!G Alpha (s) Signalling Events Pathway 1177727!!GPCR Downstream Signaling Pathway 1177726!!GPCR Ligand Binding Pathway 1177696!!Glycoprotein Hormones Pathway 1177203!!Hormone Ligand-binding Receptors Pathway 1177711!!Metabolism Pathway 1178040
ncbi summary :
mutation of the human homolog is a rare cause of hereditary hypothyrodism [RGD, Feb 2006]