Proinsulin antibody | MyBioSource MBS531105 product information

product summary

request information :

company name :

MyBioSource

product type :

antibody

product name :

Proinsulin antibody

catalog :

MBS531105

quantity :

1 mg

price :

415 USD

clonality :

monoclonal

host :

mouse

reactivity :

human

application :

enzyme immunoassay, immunohistochemistry, ELISA

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS531105

products type :

Antibody

products full name :

Proinsulin antibody

products short name :

Proinsulin

products name syn :

Monoclonal Proinsulin; Anti-Proinsulin

other names :

insulin preproprotein; Insulin; insulin; proinsulin; preproinsulin; insulin; N/A

other gene names :

INS; INS; ILPR; IRDN; IDDM2; MODY10; N/A

uniprot entry name :

INS_HUMAN

clonality :

Monoclonal

isotype :

IgG1 kappa

clone :

M32238

host :

Mouse

specificity :

Human

purity :

Proinsulin antibody was purified by chromatography on protein A Sepharose.

form :

Supplied as a liquid in PBS, with 0.1 % NaN3.

storage stability :

Store at 4 deg C.

tested application :

ELISA (EIA), Immunohistochemistry (IHC)

other info1 :

Immunogen: Proinsulin antibody was raised in mouse using human proinsulin as the immunogen.

other info2 :

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.

products categories :

Hormones & Steroids; Monoclonal Antibodies

products description :

Mouse monoclonal Proinsulin antibody. Proinsulin is the prohormone precursor to insulin made in the beta cells of the islets of Langerhans, specialized regions of the pancreas. In humans, proinsulin is encoded by the INS gene. Proinsulin is synthesized in the endoplasmic reticulum, where it is folded and its disulfide bonds are oxidized. It is then transported to the Golgi apparatus where it is packaged into secretory vesicles, and where it is processed by a series of proteases to form mature insulin.

ncbi gi num :

4557671

ncbi acc num :

NP_000198.1

ncbi gb acc num :

NM_000207.2

uniprot acc num :

P01308

ncbi mol weight :

11,981 Da

ncbi pathways :

ATF-2 Transcription Factor Network Pathway 138006!!Adipogenesis Pathway 198832!!Aldosterone-regulated Sodium Reabsorption Pathway 130626!!Aldosterone-regulated Sodium Reabsorption Pathway 130590!!Amyloids Pathway 366238!!Arf6 Trafficking Events Pathway 137954!!Developmental Biology Pathway 477129!!Diabetes Pathways 105902!!Disease Pathway 530764!!FOXA1 Transcription Factor Network Pathway 137979

ncbi summary :

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

uniprot summary :

Function: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Subunit structure: Heterodimer of a B chain and an A chain linked by two disulfide bonds. Subcellular location: Secreted. Involvement in disease: Defects in INS are the cause of familial hyperproinsulinemia (FHPRI) [. MIM:176730]. Ref.21 Ref.23 Ref.24 Ref.25Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [. MIM:125852]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Ref.34Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [. MIM:606176]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy. Ref.32 Ref.33Defects in INS are a cause of maturity-onset diabetes of the young type 10 (MODY10) [. MIM:613370]. MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Ref.33 Ref.34 Ref.35. Pharmaceutical use: Available under the names Humulin or Humalog (Eli Lilly) and Novolin (Novo Nordisk). Used in the treatment of diabetes. Humalog is an insulin analog with 52-Lys-Pro-53 instead of 52-Pro-Lys-53. Sequence similarities: Belongs to the insulin family. Sequence caution: The sequence AAA59179.1 differs from that shown. Reason: Erroneous gene model prediction.

size :

1 mg

price :

415 USD

more info or order :

MyBioSource product webpage