catalog number :
MBS531104
products full name :
Factor V antibody
products short name :
Factor V
products name syn :
Monoclonal Factor V; Anti-Factor V; Complement Factor V
other names :
factor V precusor; Coagulation factor V; coagulation factor V; coagulation factor V (proaccelerin, labile factor); Activated protein C cofactor; Proaccelerin, labile factor
other gene names :
F5; F5; FVL; PCCF; THPH2; RPRGL1
uniprot entry name :
FA5_HUMAN
form :
Supplied as a liquid with 50% Glycerol/H2O (vol/vol).
storage stability :
Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles
tested application :
ELISA (EIA), Radioimmunoassay (RIA), Western Blot (WB)
other info1 :
Biological Significance: Factor V is a large, single chain, plasma glycoprotein which is an essential component in the blood coagulation cascade. During coagulation, the procofactor, factor V, is converted to the active cofactor, factor Va, via limited proteolysis by the serine protease alpha-thrombin, and less efficiently by factor Xa.
other info2 :
Immunogen: Factor V antibody was raised in mouse using human factor V as the immunogen.
products categories :
Immunology
products description :
Mouse monoclonal Factor V antibody
ncbi acc num :
AAB59532.1
ncbi mol weight :
251,703 Da
ncbi pathways :
Blood Clotting Cascade Pathway 198840!!Common Pathway Of Fibrin Clot Formation 106060!!Complement And Coagulation Cascades Pathway 198880!!Complement And Coagulation Cascades Pathway 83073!!Complement And Coagulation Cascades Pathway 484!!Formation Of Fibrin Clot (Clotting Cascade) Pathway 106057!!Hemostasis Pathway 106028!!Platelet Activation, Signaling And Aggregation Pathway 106034!!Platelet Degranulation Pathway 106050!!Response To Elevated Platelet Cytosolic Ca2+ Pathway 106048
ncbi summary :
This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq, Oct 2008]