catalog number :
MBS531011
products full name :
AChR gamma antibody
products short name :
AChR gamma
products name syn :
Monoclonal AChR gamma; Anti-AChR gamma; Acetylcholine Receptor gamma
other names :
acetylcholine receptor subunit epsilon; Acetylcholine receptor subunit epsilon; acetylcholine receptor subunit epsilon; cholinergic receptor, nicotinic, epsilon (muscle)
products gene name :
AChR gamma
other gene names :
CHRNE; CHRNE; ACHRE; CMS1D; CMS1E; CMS2A; CMS4A; CMS4B; CMS4C; FCCMS; SCCMS; ACHRE
uniprot entry name :
ACHE_HUMAN
reactivity :
To be determined by end-user
form :
PBS with 0.1% NaN3.
storage stability :
Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles
tested application :
Flow Cytometry (FC/FACS), Immunohistochemistry (IHC) Formalin, Immunoprecipitation (IP), Western Blot (WB)
app notes :
FC: neat. IHC-F: 1:3. IP: 1:100. WB: 1:100
other info1 :
Biological Significance: An acetylcholine receptor (abbreviated AChR) is an integral membrane protein that responds to the binding of acetylcholine, a neurotransmitter. Like other transmembrane receptors, acetylcholine receptors are classified according to their "pharmacology", or according to their relative affinities and sensitivities to different molecules. Nicotinic acetylcholine receptors (nAChR), are particularly responsive to nicotine. Muscarinic acetylcholine receptors (mAChR), are particularly responsive to muscarine.
other info2 :
Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling. Immunogen: AChR gamma antibody was raised in mouse using human acetylcholine receptor as the immunogen.
products categories :
Neuroscience
products description :
Mouse monoclonal AChR gamma antibody
ncbi acc num :
NP_000071.1
ncbi gb acc num :
NM_000080.3
ncbi mol weight :
54,697 Da
ncbi pathways :
Acetylcholine Binding And Downstream Events Pathway 106535!!Activation Of Nicotinic Acetylcholine Receptors Pathway 161027!!ErbB2/ErbB3 Signaling Events Pathway 137955!!Highly Sodium Permeable Acetylcholine Nicotinic Receptors Pathway 161030!!Neuroactive Ligand-receptor Interaction Pathway 83053!!Neuroactive Ligand-receptor Interaction Pathway 462!!Neuronal System Pathway 106513!!Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway 106534!!Postsynaptic Nicotinic Acetylcholine Receptors Pathway 161031!!Presynaptic Nicotinic Acetylcholine Receptors Pathway 161028
ncbi summary :
Acetylcholine receptors at mature mammalian neuromuscular junctions are pentameric protein complexes composed of four subunits in the ratio of two alpha subunits to one beta, one epsilon, and one delta subunit. The acetylcholine receptor changes subunit composition shortly after birth when the epsilon subunit replaces the gamma subunit seen in embryonic receptors. Mutations in the epsilon subunit are associated with congenital myasthenic syndrome. [provided by RefSeq, Sep 2009]