antibody

ADRP antibody

MBS530923

0.05 mg

445 USD

monoclonal

mouse

nonconjugated

AP125

human, rat, dog, cow

western blot, immunohistochemistry, immunohistochemistry - paraffin section

Antibody

ADRP antibody

ADRP

Monoclonal ADRP; Anti-ADRP; Adipophilin

adipophilin, partial; Perilipin-2; perilipin-2; perilipin 2; Adipophilin; Adipose differentiation-related protein; ADRP

ADRP

PLIN2; PLIN2; ADFP; ADRP; ADFP; ADRP

PLIN2_HUMAN

Monoclonal

IgG1

AP125

Mouse

Dog, Human, Rat. No reactivity with Bovine and Mouse.

437

Human ADRP

Affinity purified

Lyophilized. Reconstitute in 1 ml dist. water (final solution contains 0.09 % NaN3, 0.5% BSA in PBS buffer, pH 7.4)

50ug, lyophilized

Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC) Formalin/Paraffin, Western Blot (WB)

IHC-F: 1:10

Biological Significance: Adipophilin / ADRP is a ubiquitous component of lipid droplets. It has been found in milk fat globule membranes and on the surface of lipid droplets in various cultured cell lines inducible by etomoxir. Enhanced expression of Adipophilin / ADRP is a useful marker for pathologies characterized by increased lipid droplet accumulation.

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: ADRP antibody was raised in mouse using a synthetic peptide corresponding to residues 5-27 from N-terminus of human adipophilin as the immunogen.

Nutrition & Metabolism

Mouse monoclonal ADRP antibody

1806040

CAA65989.1

Q99541

48,075 Da

Adipogenesis Pathway (198832); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); HIF-1-alpha Transcription Factor Network Pathway (138045); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); PPARA Activates Gene Expression Pathway (530749); Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway (119544)

The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]

perilipin 2: May be involved in development and maintenance of adipose tissue. Belongs to the perilipin family. Protein type: Endoplasmic reticulum. Chromosomal Location of Human Ortholog: 9p22.1. Cellular Component: endoplasmic reticulum; plasma membrane; extracellular region; lipid particle; nucleus; cytosol. Biological Process: response to drug; long-chain fatty acid transport; sequestering of lipid; cellular lipid metabolic process; response to organic cyclic substance

0.05 mg

445 USD