catalog number :
MBS530888
products full name :
CD19 antibody (Azide Free)
products short name :
CD19
products name syn :
Monoclonal CD19; Anti-CD19; CD 19; CD-19; CD19
other names :
B-lymphocyte antigen CD19 isoform 2; B-lymphocyte antigen CD19; B-lymphocyte antigen CD19; CD19 molecule; B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12; CD_antigen: CD19
products gene name :
CD19
other gene names :
CD19; CD19; B4; CVID3
uniprot entry name :
CD19_HUMAN
form :
Liquid in PBS, pH 7.4
concentration :
0.5 mg/ml
storage stability :
Aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles
tested application :
Flow Cytometry (FC/FACS), Immunohistochemistry-Frozen (IHC-F), Immunoprecipitation (IP)
app notes :
Endotoxin Level: < = 6.25 EU/ml at 0.5mg/ml as determined by LAL.
other info1 :
Biological Significance: B-lymphocyte antigen CD19 also known as CD19 (Cluster of Differentiation 19), is a protein that in humans is encoded by the CD19 gene.
other info2 :
Immunogen: CD19 antibody (Azide free) was raised in mouse using human CD19 as the immunogen.
products categories :
Immunology
products description :
Mouse monoclonal CD19 antibody (Azide Free)
ncbi acc num :
NP_001761.3
ncbi gb acc num :
NM_001770.5
ncbi mol weight :
61,200 Da
ncbi pathways :
Adaptive Immune System Pathway (366160); Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway (576249); B Cell Receptor Signaling Pathway (198909); B Cell Receptor Signaling Pathway (83081); B Cell Receptor Signaling Pathway (492); BCR Signaling Pathway (138058); Constitutive Signaling By Aberrant PI3K In Cancer Pathway (685535); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550); Disease Pathway (530764)
ncbi summary :
Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]
uniprot summary :
CD19: a cell surface molecule which assembles with the antigen receptor of B lymphocytes. A critical signal transduction molecule that regulates B lymphocyte development, activation, and differentiation. Ligation increases intracellular calcium levels and decreases the threshold for antigen receptor signaling. Germinal center formation is significantly reduced in CD19-deficient mice. Protein type: Cell surface; Membrane protein, integral. Chromosomal Location of Human Ortholog: 16p11.2. Cellular Component: protein complex; integral to plasma membrane; plasma membrane; external side of plasma membrane. Molecular Function: receptor signaling protein activity. Biological Process: epidermal growth factor receptor signaling pathway; B cell receptor signaling pathway; regulation of immune response; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; cell surface receptor linked signal transduction; nerve growth factor receptor signaling pathway; innate immune response; cellular defense response; positive regulation of release of sequestered calcium ion into cytosol. Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 3