catalog number :
MBS5308835
products type :
Recombinant Protein
products full name :
Purified recombinant Human MYD88 protein (His tag)
products short name :
[MYD88]
products name syn :
[MYD88 protein (His tag), MYD88D protein, MYD-88 protein, MYD 88 , MYD-88 , MYD88, MYD88 protein.]
other names :
[MyD88; Myeloid differentiation primary response protein MyD88]
products gene name :
[MYD88]
other gene names :
[MyD88]
sequence :
1-316aa: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMRPD RAEAPGPPAM AAGGPGAGSA APVSSTSSLP LAALNMRVRR RLSLFLNVRT QVAADWTALA EEMDFEYLEI RQLETQADPT GRLLDAWQGR PGASVGRLLE LLTKLGRDDV LLELGPSIEE DCQKYILKQQ QEEAEKPLQV AAVDSSVPRT AELAGITTLD DPLGHMPERF DAFICYCPSD IQFVQEMIRQ LEQTNYRLKL CVSDRDVLPG TCVWSIASEL IEKRCRRMVV VVSDDYLQSK ECDFQTKFAL SLSPGAHQKR LIPIKYKAMK KEFPSILRFI TVCDYTNPCT KSWFWTRLAK ALSLP
form :
Supplied in liquid form in 20mM Tris-HCI buffer (pH 8.0) containing 0.4 urea, 10% glycerol.
storage stability :
Store at 4°C for short term storage. Aliquot and store at -20°C for long term storage. Avoid repeated freeze/thaw cycles.
tested application :
SDS-PAGE
image1 heading :
SDS-Page
other info1 :
Protein Type: Recombinant. Species: Human. Tag/Conjugate: His Tag
other info2 :
Biohazard: Use standard laboratory precautions when handling this material. Biological Significance: Myeloid differentiation primary response gene 88, also known as MYD88,acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokyne secretion and the inflammatory response. This protein increases IL-8 transcription. It is involved in IL-18 mediated signaling pathway. MYD88 activated IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes.
products categories :
Signal Transduction
ncbi acc num :
AEY83971.1
ncbi mol weight :
38.7 kDa.
uniprot summary :
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.