product summary
Loading...
company name :
MyBioSource
product type :
antibody
product name :
Desmoplakin 1 antibody
catalog :
MBS530881
quantity :
0.05 mg
price :
535 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
DP2.17
reactivity :
human, mouse, rat, chicken, cow
application :
western blot, immunohistochemistry
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS530881
products type :
Antibody
products full name :
Desmoplakin 1 antibody
products short name :
Desmoplakin 1
products name syn :
Monoclonal Desmoplakin 1; Anti-Desmoplakin 1
other names :
desmoplakin isoform I; Desmoplakin; desmoplakin; desmoplakin; 250/210 kDa paraneoplastic pemphigus antigen
other gene names :
DSP; DSP; DP; DPI; DPII; DCWHKTA; DP
uniprot entry name :
DESP_HUMAN
clonality :
Monoclonal
isotype :
IgG1
clone :
DP2.17
host :
Mouse
reactivity :
Bovine, Chicken, Human, Mouse, Rat
sequence length :
2871
specificity :
Bovine desmoplakin 1
purity :
Protein A affinity chromatography
form :
Supplied as a lyophilized powder. Reconstitute in 1 ml dist. water (final solution contains 0.09 % NaN3, 0.5% BSA in PBS buffer, pH 7.4)
storage stability :
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze-thaw cycles.
tested application :
Immunohistochemistry (IHC) Formalin, Western Blot (WB)
app notes :
IHC-F: 1:10
other info1 :
Biological Significance: Desmoplakin is a protein associated with desmosomes. Desmoplakin is a protein that in humans is encoded by the DSP gene.
other info2 :
Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: Desmoplakin 1 antibody was raised in mouse using bovine desmoplakin 1 as the immunogen.
products categories :
Cell Biology
products description :
Mouse monoclonal Desmoplakin 1 antibody
ncbi gi num :
58530840
ncbi acc num :
NP_004406.2
ncbi gb acc num :
NM_004415.2
uniprot acc num :
P15924
ncbi mol weight :
278,916 Da
ncbi pathways :
Alpha6-Beta4 Integrin Signaling Pathway 198807!!Apoptosis Pathway 105648!!Apoptotic Cleavage Of Cell Adhesion Proteins Pathway 105680!!Apoptotic Cleavage Of Cellular Proteins Pathway 105678!!Apoptotic Execution Phase Pathway 105677!!Arrhythmogenic Right Ventricular Cardiomyopathy Pathway 672454!!Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway 117293!!Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway 116129!!Programmed Cell Death Pathway 1127510
ncbi summary :
Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. [provided by RefSeq, Jul 2008]
size :
0.05 mg
price :
535 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

Would you like to receive email and e-newsletter from MyBioSource about new products, special offers and events? Please click here to join our Mailing List!