This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
antibody
product name :
Estrogen Receptor antibody
catalog :
MBS530879
quantity :
0.1 mg
price :
685 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
H222
reactivity :
human, rat
application :
western blot, ELISA, enzyme immunoassay
product information
catalog number :
MBS530879
products type :
Antibody
products full name :
Estrogen Receptor antibody
products short name :
Estrogen Receptor
products name syn :
Monoclonal Estrogen Receptor; Anti-Estrogen Receptor; DKFZp686N23123; ESR-1; Era; ESR; ESR 1; ESRA
other names :
estrogen receptor isoform 1; Estrogen receptor; estrogen receptor; estrogen receptor 1; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1
other gene names :
ESR1; ESR1; ER; ESR; Era; ESRA; ESTRR; NR3A1; ESR; NR3A1; ER
uniprot entry name :
ESR1_HUMAN
clonality :
Monoclonal
isotype :
IgG1 kappa
clone :
H222
host :
Rat
reactivity :
Rat
sequence length :
595
specificity :
Human
purity :
Estrogen Receptor antibody was purified by Protein A chromatography.
form :
Antibody purified from ascites fluid by protein G chromotography and supplied in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% NaN3.
concentration :
0.2 mg/ml
storage stability :
Store at 4 degree C.
tested application :
ELISA (EIA), Western Blot (WB)
app notes :
WB: 1-2 ug/ml
other info1 :
Biological Significance: ER protein exhibits six functionally discrete domains required for transcription activation function, binding to estrogen response element (ERE) constitutive dimerization, binding to heat shock proteins, and ligand recognition. It is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors may improve response to anti-estrogen therapy.
other info2 :
Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling. Immunogen: Estrogen receptor antibody was raised in rat using estrogen receptor purified from MCF-7 cells as the immunogen.
products categories :
Hormones & Steroids
products description :
Rat monoclonal Estrogen Receptor antibody
ncbi gi num :
62821794
ncbi acc num :
NP_000116.2
ncbi gb acc num :
NM_000125.3
uniprot acc num :
P03372
ncbi mol weight :
35,547 Da
ncbi pathways :
Endocrine And Other Factor-regulated Calcium Reabsorption Pathway 213307!!Endocrine And Other Factor-regulated Calcium Reabsorption Pathway 213276!!Estrogen Signaling Pathway 799177!!Estrogen Signaling Pathway 198863!!Estrogen Signaling Pathway 799197!!FOXA1 Transcription Factor Network Pathway 137979!!FOXM1 Transcription Factor Network Pathway 137935!!Gene Expression Pathway 105937!!Generic Transcription Pathway 105938!!Integrated Breast Cancer Pathway 219801
ncbi summary :
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]
size :
0.1 mg
price :
685 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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