catalog number :
MBS5308493
products type :
Recombinant Protein
products full name :
Recombinant Human AADAC protein
products short name :
[AADAC]
products name syn :
[Arylacetamide deacetylase protein, AADAC protein, Anti-AADAC protein, DAC protein, Esterase protein]
other names :
[arylacetamide deacetylase; Arylacetamide deacetylase; arylacetamide deacetylase; arylacetamide deacetylase]
products gene name :
[AADAC]
other gene names :
[AADAC; AADAC; DAC; CES5A1; DAC]
purity :
> 85% by SDS-PAGE
form :
Liquid in 10 mM Tris-HCl, 1 mM EDTA, pH 8.0, and 10% Glycerol.
concentration :
0.1 mg/ml
storage stability :
Shipping: Blue Ice. Upon receipt, store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
tested application :
User optimized.
other info1 :
Grade: Recombinant. Species: Human. Residues: AA 24-399. Tag/Conjugate: His tag
products categories :
Signal Transduction
products description :
Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens.
ncbi acc num :
NP_001077.2
ncbi gb acc num :
NM_001086.2
ncbi summary :
Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008]
uniprot summary :
AADAC: Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also flutamide, which is an antiandrogen drug used for the treatment of prostate cancer that occasionaly causes severe hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty acids derived from hydrolysis of newly formed triglyceride stores. Belongs to the 'GDXG' lipolytic enzyme family. Protein type: Deacetylase; EC 3.1.1.3; Endoplasmic reticulum; Lipase; Membrane protein, integral; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 3q25.1. Cellular Component: endoplasmic reticulum membrane. Molecular Function: catalytic activity; deacetylase activity; lipase activity; serine hydrolase activity; triacylglycerol lipase activity. Biological Process: xenobiotic metabolic process