protein

Purified recombinant SUMO1 protein

MBS5308483

0.5 mg

375 USD

Recombinant Protein

Purified recombinant SUMO1 protein

[SUMO1]

[GAP modifying protein 1 protein, GMP 1 protein, GMP1 protein, PIC 1 protein, PIC1 protein, SENP2 protein, Sentrin 1 protein, Sentrin protein, Small ubiquitin related modifier 1 protein, SMT3 protein, SMT3 homolog 3 protein, SMT3 suppressor of mif two 3 homolog 1 protein, SMT3C protein, SMT3H3 protein, Sumo1 protein, Ubiquitin homology domain protein PIC1 protein, Ubiquitin Like 1 protein, Ubiquitin like protein SMT3C protein, Ubiquitin like protein UBL1 protein, UBL 1 protein, UBL1 protein]

[small ubiquitin-related modifier 1 isoform b; Small ubiquitin-related modifier 1; small ubiquitin-related modifier 1; small ubiquitin-like modifier 1; GAP-modifying protein 1; GMP1; SMT3 homolog 3; Sentrin; Ubiquitin-homology domain protein PIC1; Ubiquitin-like protein SMT3C; Smt3C; Ubiquitin-like protein UBL1]

[SUMO1]

[SUMO1; SUMO1; DAP1; GMP1; PIC1; SMT3; UBL1; OFC10; SENP2; SMT3C; SMT3H3; SMT3C; SMT3H3; UBL1; SUMO-1; GMP1; Smt3C]

Human

76

> 95% pure by SDS-PAGE

Lyophilized form 20mM Tris, pH 8.0 with 10mM NaCl

500ug, lyophilized

4°C shipping. Upon receipt, store at -20°C. After reconstitution store at -80°C and avoid repeat freeze/thaw cycles.

Western Blot (WB)

Western Blot (WB)

Source: E.coli. Grade: Recombinant. Biohazard: Use standard laboratory precautions when handling this material. Biological Activity: This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off.

Protein Modification & Stress Response

54792067

NP_001005782.1

NM_001005782.1

P63165

11.7kDa

Androgen Receptor Signaling Pathway (198806); Conjugation Of SUMO To E1 (UBA2:SAE1) Pathway (833808); Cytokine Signaling In Immune System Pathway (366171); Diurnally Regulated Genes With Circadian Orthologs Pathway (198813); Immune System Pathway (106386); Interferon Signaling Pathway (187103); Interferon Gamma Signaling Pathway (187106); Nuclear Pore Complex Pathway (470351); Processing And Activation Of SUMO Pathway (833806); Proteolytic Processing Of SUMO Pathway (833807)

This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

SUMO1: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Interacts with SAE2, UBE2I, RANBP2, PIAS1 and PIAS2. Interacts with PARK2. Covalently attached to a number of proteins such as IKFZ1, PML, RANGAP1, HIPK2, SP100, p53, p73-alpha, MDM2, JUN, DNMT3B and TDG. Also interacts with HIF1A, HIPK2, HIPK3, CHD3, EXOSC9, RAD51 and RAD52. Interacts with USP25 (via ts SIM domain); the interaction weakly sumoylates USP25. Belongs to the ubiquitin family. SUMO subfamily. Protein type: Nuclear receptor co-regulator; Ubiquitin-like modifier. Chromosomal Location of Human Ortholog: 2q33.1. Cellular Component: nuclear body; nuclear membrane; nuclear pore; nucleolus; nucleoplasm; nucleus; plasma membrane; PML body; voltage-gated potassium channel complex. Molecular Function: potassium channel regulator activity; protein binding; protein tag; transcription factor binding; ubiquitin protein ligase binding. Biological Process: DNA repair; double-strand break repair via nonhomologous end joining; negative regulation of action potential; negative regulation of DNA binding; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; palate development; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein complex assembly; protein stabilization; protein sumoylation; regulation of protein localization. Disease: Orofacial Cleft 10

0.5 mg

375 USD