protein

Purified native Troponin I protein (Skeletal Muscle)

MBS5308434

0.1 mg

1215 USD

Native Protein

Purified native Troponin I protein (Skeletal Muscle)

[Troponin I]

[Troponin I protein (Skeletal Muscle)]

[troponin I; troponin I]

Human Skeletal Muscle

172

> 95% pure by SDS-PAGE.

Lyophilized in 0.01M HCl. Reconstitute in Urea/Tris buffer: 0.02M Tris, 7M Urea, 5mM EDTA and 15mM mercaptoethanol, pH 7.5. Solubility is limited at neutral pH and Physiological salt concentration.

Shipping: Blue Ice. Upon receipt store at -20°C.

Protein type: native

Biohazard: Tissue Donor was tested and found negative fo HBsAg, HIV-1 and HIV-2 anitbodies, HCV and Syphillis. However, because no test can guarantee absence of infectious material, use standard laboratory precautions. Biological Significance: Troponin I is a part of the troponin complex. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle. The letter I is given due to its inhibitory character.

Cardiac Markers

0.1 mg

1215 USD