catalog number :
MBS5308352
products type :
Native Protein
products full name :
Purified native Human Kallikrein protein
products short name :
[Kallikrein]
products name syn :
[Kallikrein protein]
other names :
[kallikrein; Kallikrein-1; kallikrein-1; kallikrein 1; Kidney/pancreas/salivary gland kallikrein; Tissue kallikrein]
other gene names :
[KLK1; KLK1; hK1; KLKR; Klk6]
purity :
>=95% by SDS-PAGE.
form :
Liquid in 20 mM Tris-HCI, pH 7.8 with 100 mM NaCI.
concentration :
0.552 mg/mL
storage stability :
Shipping: Blue Ice. Upon receipt store at -70°C . Avoid freeze-thaw cycle.
image1 heading :
SDS-Page
other info1 :
Biohazard: Prepared form plasma shown to be non-reactive for HBsAg, anti-HCV, anti-HBc and negative for anti-HIV 1&2 by FDA approved tests.
other info2 :
Additional Remarks: Activity: 15 units per mg.
products categories :
Proteases; Inhibitors; & Enzymes
ncbi acc num :
AAA36136.1
ncbi pathways :
Blood Clotting Cascade Pathway (198840); Endocrine And Other Factor-regulated Calcium Reabsorption Pathway (213307); Endocrine And Other Factor-regulated Calcium Reabsorption Pathway (213276); Metabolism Of Proteins Pathway (1268677); Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway (1268755); Renin-angiotensin System Pathway (83075); Renin-angiotensin System Pathway (486)
ncbi summary :
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008]
uniprot summary :
KLK1: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Belongs to the peptidase S1 family. Kallikrein subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.4.21.35; Protease. Chromosomal Location of Human Ortholog: 19q13.33. Cellular Component: nucleus. Disease: Kallikrein, Decreased Urinary Activity Of