AChE antibody | MyBioSource MBS530832 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

AChE antibody

catalog :

MBS530832

quantity :

0.2 mL

price :

745 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

HR2

reactivity :

human, cow

application :

ELISA, immunohistochemistry, immunoprecipitation, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS530832

products type :

Antibody

products full name :

AChE antibody

products short name :

AChE

products name syn :

Monoclonal AChE; Anti-AChE; Acetylcholinesterase

other names :

acetylcholinesterase; Acetylcholinesterase; acetylcholinesterase; acetylcholinesterase (Yt blood group)

products gene name :

AChE

other gene names :

ACHE; ACHE; YT; ACEE; ARACHE; N-ACHE; AChE

uniprot entry name :

ACES_HUMAN

clonality :

Monoclonal

isotype :

IgG2b

clone :

HR2

host :

Mouse

reactivity :

Bovine, Cat, Guinea Pig, Human, Rabbit

sequence length :

614

specificity :

Human

form :

PBS with 0.05% NaN3.

concentration :

1.0 mg/ml

storage stability :

Aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles.

tested application :

ELISA (EIA), Immunohistochemistry (IHC) Formalin, Immunoprecipitation (IP)

app notes :

IHC-F: 1:50

other info1 :

Biological Significance: Acetylcholinesterase, also known as AChE, is an enzyme responsible for the hydrolytic degradation of the neurotransmitter acetylcholine, producing choline and an acetate group. AchE is found at neuromuscular junctions and cholinergic nervous system, where its activity serves to terminate synaptic transmission.

other info2 :

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: AChE antibody was raised in mouse using purified human cerebellar acetylcholinesterase as the immunogen.

products categories :

Neuroscience

products description :

Mouse monoclonal AChE antibody

ncbi gi num :

177975

ncbi acc num :

AAA68151.1

uniprot acc num :

P22303

ncbi mol weight :

58,352 Da

ncbi pathways :

ATF-2 Transcription Factor Network Pathway (138006); Acetylcholine Synthesis Pathway (198820); Biogenic Amine Synthesis Pathway (198793); Cholinergic Synapse Pathway (217716); Glycerophospholipid Biosynthesis Pathway (645313); Glycerophospholipid Metabolism Pathway (82989); Glycerophospholipid Metabolism Pathway (364); Integrated Pancreatic Cancer Pathway (711360); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976)

ncbi summary :

Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq, Jul 2008]

uniprot summary :

ACHE: Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis. Belongs to the type-B carboxylesterase/lipase family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Hydrolase; Lipid Metabolism - glycerophospholipid; Membrane protein, GPI anchor; EC 3.1.1.7. Chromosomal Location of Human Ortholog: 7q22. Cellular Component: Golgi apparatus; extracellular space; cell surface; membrane; perinuclear region of cytoplasm; plasma membrane; extracellular region; basal lamina; synapse; neuromuscular junction; nucleus; cell junction. Molecular Function: collagen binding; protein binding; serine hydrolase activity; protein homodimerization activity; cholinesterase activity; protein self-association; hydrolase activity; beta-amyloid binding; laminin binding; acetylcholinesterase activity; acetylcholine binding. Biological Process: nervous system development; negative regulation of synaptic transmission, cholinergic; muscle development; acetylcholine catabolic process in synaptic cleft; acetylcholine catabolic process; glycerophospholipid biosynthetic process; osteoblast development; cell proliferation; synaptic transmission; synaptogenesis; positive regulation of protein secretion; amyloid precursor protein metabolic process; retina development in camera-type eye; neurotransmitter receptor biosynthetic process; receptor internalization; phospholipid metabolic process; response to wounding; phosphatidylcholine biosynthetic process; regulation of receptor recycling; DNA replication; cell adhesion; protein tetramerization; neurotransmitter biosynthetic process. Disease: Yt Blood Group Antigen

size1 :

0.2 mL

price1 :

745 USD

more info or order :

MyBioSource product webpage