catalog number :
MBS5308267
products type :
Native Protein
products full name :
Purified Native Bordetella pertussis FHA protein
products short name :
[Bordetella pertussis FHA]
products name syn :
[Bordetella pertussis FHA protein]
purity :
> 98% by SDS-PAGE
form :
Lyophilized powder. Reconsitute with 193ul of distilled water for a solution of approximately 0.5mg/ml of FHA in 0.05M Tris-HCl, 0.5M Sodium Chloride, 5%M Sodium Chloride, 5% Sucrose at pH 8.0. Note: This product sticks to plastic and glass, concen
concentration :
100 ug/ml lyophilized powder
storage stability :
Store at 4 degree C.
other info1 :
Source Note: Purified FHA from B. pertussis strain NC10739/ACTC9797. Protein Type: Native. Biological Significance: Pertussis toxin (PT) is a protein-based AB5-type exotoxin produced by the bacterium Bordetella pertussis, which causes whooping cough. PT is involved in the colonization of the respiratory tract and the establishment of infection. Research suggests PT may have a therapeutic role in treating a number of common human ailments, including hypertension, viral inhibition, and autoimmune inhibition. Implications in Disease: Pertussis (or whooping cough) is an infection of the respiratory system characterized by a “whooping” sound when the person breathes in. B. pertussis has the ability to inhibit the function of the host's immune system. The toxin, known as pertussis toxin (or PTx), inhibits G protein coupling that regulates an adenylate cyclase-mediated conversion of ATP to cyclic AMP. The end result is phagocytes convert too much ATP to cyclic AMP, which can cause disturbances in cellular signaling mechanisms, and prevent phagocytes from correctly responding to an infection. The infection occurs mostly in children under the age of one when they are unimmunized, or children with faded immunity, normally around the ages 11 through 18. The signs and symptoms are similar to a common cold: runny nose, sneezing, mild cough, and low-grade fever. The patient becomes most contagious during the catarrhal stage of infection, normally two weeks after the coughing begins.
other info2 :
Note: This product is present as 95% in its original 220 kda form with 5% reported breakdown products or 140kda and 90 kda.
products categories :
Infectious Disease