catalog number :
MBS530770
products full name :
Drebrin antibody
products short name :
Drebrin
products name syn :
Monoclonal Drebrin; Anti-Drebrin
other names :
drebrin isoform a; Drebrin; drebrin; drebrin 1; Developmentally-regulated brain protein
other gene names :
DBN1; DBN1; D0S117E; D0S117E
uniprot entry name :
DREB_HUMAN
reactivity :
Bovine, Dog, Human, Mouse, Rat
form :
Supplied as ascites fluid from Balb/c mice.
storage stability :
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
tested application :
Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin, Immunoprecipitation (IP), Western Blot (WB)
other info1 :
Biological Significance: Drebrin is a widespread actin-associating protein of 70 kDa. It is enriched at junctional plaques, defining a specific microfilament anchorage system in polar epithelial cells.
other info2 :
Immunogen: Drebrin antibody was raised in mouse using a synthetic c-terminal peptide coupled KLH as the immunogen.
products categories :
Neuroscience
products description :
Mouse monoclonal Drebrin antibody
ncbi acc num :
NP_004386.2
ncbi gb acc num :
NM_004395.3
ncbi mol weight :
76,300 Da
ncbi summary :
The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]