antibody

CEA antibody (in PBS)

MBS530761

1 mg

245 USD

monoclonal

mouse

nonconjugated

M111146

ELISA, enzyme immunoassay

Antibody

CEA antibody (in PBS)

CEA

Monoclonal CEA; Anti-CEA; Carcinoembryonic Antigen

carcinoembryonic antigen, partial; Carcinoembryonic antigen-related cell adhesion molecule 6; carcinoembryonic antigen-related cell adhesion molecule 6; carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen); Non-specific crossreacting antigen; Normal cross-reacting antigen; CD_antigen: CD66c

CEA

CEACAM6; CEACAM6; NCA; CEAL; CD66c; NCA

CEAM6_HUMAN

Monoclonal

IgG1

M111146

Mouse

CEA 100%

141

Chromatographically purified, supplied in PBS buffer, pH 7.5 with 0.05% Na Azide

6.8mg/ml

Store at 4 degree C

ELISA (EIA)

MBS530761 can be used as a detection antibody in an ELISA assay using MBS530175 as the capture antibody

Biological Significance: Carcinoembryonic antigen (CEA) is a glycoprotein involved in cell adhesion. It is normally produced during fetal development, but the production of CEA stops before birth. Therefore, it is not usually present in the blood of healthy adults, although levels are raised in heavy smokers. CEA is a glycosyl phosphatidyl inositol (GPI)-cell surface anchored glycoprotein whose specialized sialofucosylated glycoforms serve as functional colon carcinoma L-selectin and E-selectin ligands, which may be critical to the metastatic dissemination of colon carcinoma cells.

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: Purified natural CEA. Affinity Constant: ~5.0 x 10 10 L/M

Cancer

Mouse monoclonal CEA antibody

553222

AAA51971.1

Cell Surface Interactions At The Vascular Wall Pathway (106062); Extracellular Matrix Organization Pathway (576262); Fibronectin Matrix Formation Pathway (771601); Hemostasis Pathway (106028)

This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]

CEACAM6: Belongs to the immunoglobulin superfamily. CEA family. Protein type: Membrane protein, integral; Membrane protein, GPI anchor. Chromosomal Location of Human Ortholog: 19q13.2. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: protein binding. Biological Process: cell-cell signaling; signal transduction; blood coagulation; leukocyte migration

1 mg

245 USD