antibody

Mouse monoclonal Glycated Hemoglobin (HbA1c) antibody

MBS5306250

1 mg

375 USD

monoclonal

mouse

nonconjugated

[M81865]

ELISA, enzyme immunoassay

Antibody

Mouse monoclonal Glycated Hemoglobin (HbA1c) antibody

[HbA1c]

[HbA1c antibody, Glycated Hemoglobin antibody, Hemoglobin A1c antibody, Monoclonal HbA1c antibody, Anti-Hemoglobin antibody, Haemoglobin antibody, Anti HbA1c antibody]

[hemoglobin subunit alpha; Hemoglobin subunit alpha; hemoglobin subunit alpha; hemoglobin subunit alpha 1; Alpha-globin; Hemoglobin alpha chain]

[HbA1c]

[HBA1; HBA1; HBH; HBA-T3]

Monoclonal

IgG

[M81865]

Mouse

142

> 90% pure

Liquid. Purified from ascites, supplied in 10mM PBS buffer, pH 7.4 with 0.1% P300

5.0 mg/ml

Store at 4°C for up to 2 weeks, or -20°C long term

ELISA (EIA), Immunoassays

Immunogen: Native human glycated hemoglobin. Biological Significance: Hemoglobin is found in red blood cells and is responsible forcarrying oxygen throughoutthe body. In diabetes mellitus,sugar builds up inthe blood and combines with hemoglobin, becoming "glycated." Hemoglobin A1c (or HbA1c)levels are measured to determine the average amount of sugar in your blood. Higher levels of HbA1c in the range of 6.5%indicate diabetes, with risk developing at greater than 4% HbA1c. Point of care kits use Boronate affinity chromatography and immunoasays to detect HbA1c, but ELISA and HPLC are also commonly used diagnostic tests for HbA1c.

Nutrition & Metabolism

4504347

NP_000549.1

NM_000558.4

P69905

15,258 Da

African Trypanosomiasis Pathway (194384); African Trypanosomiasis Pathway (194323); Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Malaria Pathway (152665); Malaria Pathway (152657); Metabolism Pathway (477135); O2/CO2 Exchange In Erythrocytes Pathway (645346); Scavenging Of Heme From Plasma Pathway (771600); Selenium Pathway (198825); Uptake Of Carbon Dioxide And Release Of Oxygen By Erythrocytes Pathway (645347)

The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported. [provided by RefSeq, Jul 2008]

HBA1: Involved in oxygen transport from the lung to the various peripheral tissues. Defects in HBA1 may be a cause of Heinz body anemias (HEIBAN). This is a form of non-spherocytic hemolytic anemia of Dacie type 1. After splenectomy, which has little benefit, basophilic inclusions called Heinz bodies are demonstrable in the erythrocytes. Before splenectomy, diffuse or punctate basophilia may be evident. Most of these cases are probably instances of hemoglobinopathy. The hemoglobin demonstrates heat lability. Heinz bodies are observed also with the Ivemark syndrome (asplenia with cardiovascular anomalies) and with glutathione peroxidase deficiency. Defects in HBA1 are the cause of alpha-thalassemia (A- THAL). The thalassemias are the most common monogenic diseases and occur mostly in Mediterranean and Southeast Asian populations. The hallmark of alpha-thalassemia is an imbalance in globin-chain production in the adult HbA molecule. The level of alpha chain production can range from none to very nearly normal levels. Deletion of both copies of each of the two alpha-globin genes causes alpha(0)-thalassemia, also known as homozygous alpha thalassemia. Due to the complete absence of alpha chains, the predominant fetal hemoglobin is a tetramer of gamma-chains (Bart hemoglobin) that has essentially no oxygen carrying capacity. This causes oxygen starvation in the fetal tissues leading to prenatal lethality or early neonatal death. The loss of three alpha genes results in high levels of a tetramer of four beta chains (hemoglobin H), causing a severe and life-threatening anemia known as hemoglobin H disease. Untreated, most patients die in childhood or early adolescence. The loss of two alpha genes results in mild alpha-thalassemia, also known as heterozygous alpha-thalassemia. Affected individuals have small red cells and a mild anemia (microcytosis). If three of the four alpha-globin genes are functional, individuals are completely asymptomatic. Some rare forms of alpha-thalassemia are due to point mutations (non- deletional alpha-thalassemia). The thalassemic phenotype is due to unstable globin alpha chains that are rapidly catabolized prior to formation of the alpha-beta heterotetramers. Alpha(0)-thalassemia is associated with non-immune hydrops fetalis, a generalized edema of the fetus with fluid accumulation in the body cavities due to non-immune causes. Non- immune hydrops fetalis is not a diagnosis in itself but a symptom, a feature of many genetic disorders, and the end-stage of a wide variety of disorders. Defects in HBA1 are the cause of hemoglobin H disease (HBH). HBH is a form of alpha-thalassemia due to the loss of three alpha genes. This results in high levels of a tetramer of four beta chains (hemoglobin H), causing a severe and life-threatening anemia. Untreated, most patients die in childhood or early adolescence. Belongs to the globin family. Protein type: Carrier. Chromosomal Location of Human Ortholog: 16p13.3. Cellular Component: cytosol; extracellular region; hemoglobin complex; membrane. Molecular Function: haptoglobin binding; peroxidase activity; protein binding. Biological Process: bicarbonate transport; hydrogen peroxide catabolic process; oxygen transport; protein heterooligomerization; receptor-mediated endocytosis; response to hydrogen peroxide. Disease: Alpha-thalassemia; Heinz Body Anemias; Hemoglobin H Disease

1 mg

375 USD