catalog number :
MBS530581
products full name :
Thyroglobulin antibody
products short name :
Thyroglobulin
products name syn :
Monoclonal Thyroglobulin; Anti-Thyroglobulin; Thyroglobulin; hTg; Tg; Anti Thyroglobulin
other names :
thyroglobulin; Thyroglobulin; thyroglobulin; thyroglobulin
other gene names :
TG; TG; TGN; AITD3; Tg
uniprot entry name :
THYG_HUMAN
purity :
Thyroglobulin antibody was purified by chromatography on protein G Sepharose.
form :
Purified from murine ascites and supplied in PBS, pH 7.4, 0.1 % NaN3.
storage stability :
Store at 4 degree C.
tested application :
ELISA (EIA)
app notes :
MBS530581 can be used as the capture antibody in a matched pair immunoassay in conjunction with MBS531053 as the detection antibody
other info1 :
Biological Significance: Thyroglobulin (Tg) is a 660 kDa, dimeric protein produced by and used entirely within the thyroid gland. Tg is used by the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3). It is presumed that Tg and the thyroid are important for the storage of iodine.
other info2 :
Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: Thyroglobulin antibody was raised in mouse using human thyroblogulin as the immunogen.
products categories :
Hormones & Steroids
products description :
Mouse monoclonal Thyroglobulin antibody
ncbi acc num :
CAA29104.1
ncbi mol weight :
298,383 Da
ncbi pathways :
Autoimmune Thyroid Disease Pathway 83121!!Autoimmune Thyroid Disease Pathway 533!!Thyroid Hormone Synthesis Pathway 835410!!Thyroid Hormone Synthesis Pathway 839541!!Thyroxine (Thyroid Hormone) Production Pathway 920992
ncbi summary :
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]