MyBioSource

antibody

Insulin+Proinsulin antibody

MBS530567

1 mg

440 USD

monoclonal

mouse

human

immunohistochemistry, enzyme immunoassay, ELISA

MBS530567

Antibody

Insulin+Proinsulin antibody

Insulin+Proinsulin

Monoclonal Insulin+Proinsulin; Anti-Insulin+Proinsulin; Anti Insulin+Proinsulin; Insulin/Proinsulin; Insulin & Proinsulin; Insulin/Proinsulin; Insulin & Proinsulin; Insulin+Proinsulin

insulin preproprotein; Insulin; insulin; proinsulin; preproinsulin; insulin; N/A

INS; INS; ILPR; IRDN; IDDM2; MODY10; N/A

INS_HUMAN

Monoclonal

IgG1 kappa

M322216

Mouse

Human, bovine, pig

Rat/Murine

Insulin+Proinsulin antibody was purified by chromatography on protein A Sepharose.

Supplied as a liquid in PBS, with 0.1 % NaN3.

Store at 4 deg C.

ELISA (EIA), Immunohistochemistry (IHC) (Formalin)

10-I34B can be used as the conjugate antibody with 10-I34A as the coating antibody

Immunogen: Insulin/proinsulin antibody was raised in mouse using purified mouse Insulin and proinsulin as the immunogen.

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.

Hormones & Steroids; Monoclonal Antibodies

Mouse monoclonal Insulin+Proinsulin antibody. Insulin is a hormone that is central to regulating carbohydrate and fat metabolism in the body. Insulin causes cells in the liver, muscle, and fat tissue to take up glucose from the blood, storing it as glycogen in the liver and muscle. Proinsulin is the prohormone precursor to insulin made in the beta cells of the islets of Langerhans, specialized regions of the pancreas. In humans, proinsulin is encoded by the INS gene.

4557671

NP_000198.1

NM_000207.2

P01308

11,981 Da

AGE/RAGE Pathway 698754!!ATF-2 Transcription Factor Network Pathway 138006!!Adipogenesis Pathway 198832!!Aldosterone-regulated Sodium Reabsorption Pathway 130626!!Aldosterone-regulated Sodium Reabsorption Pathway 130590!!Amyloids Pathway 366238!!Arf6 Trafficking Events Pathway 137954!!Cardiac Progenitor Differentiation Pathway 712094!!Developmental Biology Pathway 477129!!Disease Pathway 530764

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

Function: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Subunit structure: Heterodimer of a B chain and an A chain linked by two disulfide bonds. Subcellular location: Secreted. Involvement in disease: Hyperproinsulinemia, familial (FHPRI) [MIM:176730]: An autosomal dominant condition characterized by elevated levels of serum proinsulin-like material.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.21 Ref.23 Ref.24 Ref.25Diabetes mellitus, insulin-dependent, 2 (IDDM2) [MIM:125852]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.34Diabetes mellitus, permanent neonatal (PNDM) [MIM:606176]: A rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.32 Ref.33Maturity-onset diabetes of the young 10 (MODY10) [MIM:613370]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.33 Ref.34 Ref.35. Pharmaceutical use: Available under the names Humulin or Humalog (Eli Lilly) and Novolin (Novo Nordisk). Used in the treatment of diabetes. Humalog is an insulin analog with 52-Lys-Pro-53 instead of 52-Pro-Lys-53. Sequence similarities: Belongs to the insulin family. Sequence caution: The sequence AAA59179.1 differs from that shown. Reason: Erroneous gene model prediction.

1 mg

440 USD