catalog number :
MBS530522
products full name :
MBP antibody
products short name :
MBP
products name syn :
Monoclonal MBP; Anti-MBP; Anti MBP; Myelin Basic Protein; MBP
other names :
Myelin basic protein; Myelin basic protein; Golli-MBP; myelin basic protein; myelin basic protein; Myelin A1 protein; Myelin membrane encephalitogenic protein
other gene names :
MBP; MBP; MBP
uniprot entry name :
MBP_HUMAN
reactivity :
To be determined by end-user
form :
PBS, pH 7.5, with 0.1% NaN3.
storage stability :
Store at 4 degree C.
tested application :
User optimized
other info1 :
Biological Significance: Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the central nervous system (CNS).
other info2 :
Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: MBP antibody was raised in mouse using human MBP as the immunogen.
products categories :
Neuroscience
products description :
Mouse monoclonal MBP antibody
ncbi mol weight :
17,343 Da
ncbi pathways :
Glial Cell Differentiation Pathway 698758!!MAPK Cascade Pathway 198834!!Neural Crest Differentiation Pathway 672460!!Spinal Cord Injury Pathway 739007
ncbi summary :
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]