antibody

Eosinophil Major Basic Protein Antibody

MBS530470

0.1 mg

430 USD

monoclonal

mouse

nonconjugated

BMK13

western blot, ELISA, immunohistochemistry, enzyme immunoassay, immunohistochemistry - paraffin section

Antibody

Eosinophil Major Basic Protein Antibody

Eosinophil Major Basic

Monoclonal Eosinophil Major Basic Protein; Anti-Eosinophil Major Basic Protein; MRP

eosinophil major basic protein; Bone marrow proteoglycan; bone marrow proteoglycan; proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein); Proteoglycan 2

PRG2; PRG2; MBP; BMPG; MBP1; MBP; BMPG; EMBP; MBP

PRG2_HUMAN

Monoclonal

IgG1

BMK13

Mouse

To be determined by end-user

222

Human

Was purified by affinity chromatography.

PBS with 10mM NaN3 and 1 mg/ml BSA.

0.1 mg/ml

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

ELISA (EIA), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

Biological Significance: Structurally the major basic protein (MBP) is similar to lectins (sugar-binding proteins), and has a fold similar to that seen in C-type lectins. Two crystallographic structures of MBP have been determined. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases.

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling. Immunogen: Eosinophil major basic protein antibody was raised in mouse using human eosinophil major basic protein as the immunogen.

Immunology

Mouse monoclonal Eosinophil Major Basic Protein Antibody

306839

AAA35965.1

P13727

23,901 Da

Asthma Pathway 83120!!Asthma Pathway 532

The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

0.1 mg

430 USD