protein

Amylin protein

MBS5304623

0.05 mg

280 USD

Recombinant Protein

Amylin protein

[Amylin]

[Amylin protein; Diabetes associated peptide protein; DAP protein; Insulinoma amyloid peptide protein; Islet amyloid polypeptide protein]

[amylin, partial; Islet amyloid polypeptide; islet amyloid polypeptide; islet amyloid polypeptide; Amylin; Diabetes-associated peptide; DAP; Insulinoma amyloid peptide]

[IAPP; IAPP; DAP; IAP; DAP]

IAPP_HUMAN

E. coli

62

> 90% by SDS-PAGE

Liquid in PBS, pH 7.4, with 20mM GSH.

0.15 mg/ml

Ships on blue ice. Upon receipt, store at -20°C. Avoid repeat freeze-thaw cycles.

ELISA (EIA), SDS-PAGE, Western Blot (WB)

SDS-PAGE

Grade: Recombinant human. Species: Human

Nutrition & Metabolism

Amylin selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.

457131

AAA35524.1

31 kDa

Amyloids Pathway (366238); Calcitonin-like Ligand Receptors Pathway (106379); Class B/2 (Secretin Family Receptors) Pathway (106378); Developmental Biology Pathway (477129); Disease Pathway (530764); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Integrated Pancreatic Cancer Pathway (711360); Maturity Onset Diabetes Of The Young Pathway (83096)

The protein encoded by this gene is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. Studies suggest that this protein, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. This protein also exhibits an bactericidal, antimicrobial activity. [provided by RefSeq, Sep 2014]

IAPP: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. Belongs to the calcitonin family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 12p12.1. Cellular Component: extracellular space; cell soma; extracellular region. Molecular Function: identical protein binding; hormone activity; receptor binding. Biological Process: negative regulation of cell differentiation; cell-cell signaling; apoptosis; eating behavior; sensory perception of pain; signal transduction; negative regulation of bone resorption; endocrine pancreas development

0.05 mg

280 USD