protein

NGAL protein (Pig)

MBS5304351

1 mL

410 USD

Recombinant Protein

NGAL protein (Pig)

[NGAL]

[NNE protein; Neutrophil gelatinase-associated lipocalin protein; Lipocalin-2 protein; MSFI protein; Porcine NGAL protein; Oncogene 24p3 protein; p25 protein; HNL protein; LCN2 protein; LCN-2 protein; LCN 2; 2 phospho D glycerate hydrolyase protein; Phosphopyruvate hydratase protein; Plasminogen binding protein; alpha enolase protein; C myc promoter binding protein; Enolase 1 protein; MBP1 protein; Non neural enolase protein]

[neutrophil gelatinase-associated lipocalin; Neutrophil gelatinase-associated lipocalin; neutrophil gelatinase-associated lipocalin; lipocalin 2; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Oncogene 24p3; Siderocalin LCN2; p25]

[NGAL]

[LCN2; LCN2; 24p3; MSFI; NGAL; HNL; NGAL; NGAL]

NGAL_HUMAN

198

Liquid in 0.01M Phosphate buffer, ph 7.4, with 0.14 NaCI, 0.5% BSA, 0.5% BSA, 0.5% Tween 20, 0.0016% Phenol red, and 0.1% Proclin 950

400 pg/mL

Store at 4°C

ELISA (EIA)

MBS5304351 can be used as a standard in NGAL quantifying assays, such as ELISA.

Source: E.coli. Species: Pig. Grade: Recombinant. Biohazard: For research use only. Use standard laboratory precautions when handling. Assay Information: MBS5304351 can be used as a standard in NGAL quantifying assays, such as ELISA. Biohazard: For research use only. Use standard laboratory precautions when handling.

Biological Significance: NGAL is expressed and secreted by immune cells, hepatocytes , and renal tubular cells in various pathalogic states. NAGAL exerts bacteriostatic effects, which are explained by its ability to capture and deplete siderohores, small iron-binding molecules that are syntesized by certain bacteria as a means of iron acquistion.

Proteases, Inhibitors, & Enzymes

Purified recombinant Pig NGAL protein

38455402

NP_005555.2

NM_005564.3

22,457 Da

Iron Uptake And Transport Pathway (187191); Transmembrane Transport Of Small Molecules Pathway (106572)

LCN2: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. Belongs to the calycin superfamily. Lipocalin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 9q34. Cellular Component: extracellular space; extracellular region; cytosol. Molecular Function: protein homodimerization activity; protease binding; transporter activity; iron ion binding. Biological Process: response to drug; cellular response to nutrient levels; cellular iron ion homeostasis; response to virus; positive regulation of cell projection organization and biogenesis; siderophore transport; innate immune response; ion transport; response to herbicide; transmembrane transport

1 mL

410 USD